PMID: 7370956Apr 15, 1980Paper

Studies of the goitrogenic and tumorigenic effect of two goitrogens in combination with hypophysectomy or thyroid hormone treatment

Cancer
B Jemec

Abstract

The influence of hypophysectomy, triiodothyronine (T3), and thyroxine (T4) on the goitrogenic and tumorigenic activity of methylthiouracil (MTU) and 1-methyl-2-mercapto imidazol (MMI) was studied in rats. Hypophysectomy effectively prevented the development of thyroid hyperplasia and adenomas in MTU-treated animals. T3 reduced or abolished the weight loss of goitrogen-treated animals, and prevented the development of thyroid hyperplasia, adenomas, and pulmonary metastatic nodules. The effect of T4 was less pronounced, especially in MTU-treated animals. This hormone failed to neutralize the goitrogenic effect of MTU but it did reduce significantly the incidence of thyroid adenomas and prevented the appearance of pulmonary lesions. The biological effect of the thyroid hormones correlated with their effect on the serum levels of TSH, T3, and T4. The observations are compatible with the assumption that the tumorigenic effect of the two goitrogens depends upon a state of imbalance between TSH and T3.

References

Apr 1, 1972·The Journal of Clinical Endocrinology and Metabolism·N FleischerM Calderon
Oct 1, 1960·Endocrinology·G M JAGIELLO, J M McKENZIE
May 1, 1962·Acta Endocrinologica·E A SELLERS, E SCHONBAUM
Nov 1, 1951·The Journal of Clinical Endocrinology and Metabolism·H P MORRISC D GREEN
Dec 1, 1949·British Journal of Cancer·F BIELSCHOWSKY, W E GRIESBACH
Dec 1, 1949·British Journal of Cancer·W H HALL, F BIELSCHOWSKY
Aug 19, 1950·Journal of the American Medical Association·W S REVENO, H ROSENBAUM
Jan 1, 1946·Acta Pharmacologica Et Toxicologica·E FREIESLEBEN, K KJERULF-JENSEN

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Citations

Aug 19, 2007·The Journal of Clinical Investigation·Jukka KeroStefan Offermanns
Dec 1, 1991·Anatomia, histologia, embryologia·A Fernandez RodriguezJ Fernandez Sanz
Jul 29, 1998·Environmental Health Perspectives·R N HillD V Singh
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Meyer Knobel, Geraldo Medeiros-Neto

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