PMID: 520125Mar 1, 1979Paper

Studies of the HLA system and insulin-dependent diabetes mellitus

Diabetes Care
M ChristyA Svejgaard

Abstract

The relationship between the HLA system and insulin-dependent diabetes mellitus (IDDM) is reviewed. Data compiled by the HLA and Disease Registry reveal that HLA-B8 and/or Dw3 are associated with IDDM in all populations studied so far, but further population studies in non-Caucasian populations should be performed. In Caucasians, HLA-Dw2 renders protection against IDDM while HLA-Dw3 and Dw4 are associated with susceptibility to IDDM. The exact mode of inheritance of susceptibility to IDDM remains to be established. Involvement of at least two genes is likely. Heterogeneity of IDDM is highly possible and should be a matter of major interest in diabetes research.

Citations

Jan 1, 1981·Human Genetics·C Rittner, J Bertrams
Sep 1, 1980·Diabetologia·I DeschampsJ Hors
Jan 1, 1983·Immunogenetics·C NordlanderC I Smith
Aug 1, 1980·Diabetologia·M G HammondM A Omar
Jan 1, 1980·Diabetologia·J A SachsH Festenstein
Apr 1, 1986·Acta diabetologica latina·V MohanM Viswanathan
Jul 1, 1984·Irish Journal of Medical Science·R McKennaC F McCarthy
May 1, 1988·Human Immunology·J R RoweM J Sheehy
Jun 1, 1991·Baillière's Clinical Endocrinology and Metabolism·M J Sheehy
Dec 20, 1979·The New England Journal of Medicine·C A StanleyL Baker
May 7, 1981·The New England Journal of Medicine·S SrikantaM C Vaidya
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M J MacDonaldK L Winter
Sep 1, 1981·Australian Paediatric Journal·J W Cox, G M Bourke
Oct 1, 1980·Annals of Human Genetics·R S SpielmanC M Zmijewski
May 1, 1980·Annals of Human Genetics·S E HodgeK L Lange
Jun 1, 1983·Annals of the Rheumatic Diseases·D J ThomasA G Cudworth
Mar 1, 1989·The Journal of Clinical Investigation·M J SheehyB S Nepom
Mar 1, 1988·Ophthalmic Paediatrics and Genetics·T MattinaF Mollica
Jan 1, 1985·Scandinavian Journal of Rheumatology·N MorlingK Thomsen
Dec 6, 2003·Pediatric Diabetes·Joel N Hirschhorn
Aug 1, 1987·Seminars in Arthritis and Rheumatism·T Gordon, D Isenberg
Oct 1, 1981·Metabolism: Clinical and Experimental·S SrikantaM M Ahuja
Dec 1, 1989·Clinical Immunology and Immunopathology·R Wassmuth, A Lernmark

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