Studies of the HLA system and insulin-dependent diabetes mellitus
The relationship between the HLA system and insulin-dependent diabetes mellitus (IDDM) is reviewed. Data compiled by the HLA and Disease Registry reveal that HLA-B8 and/or Dw3 are associated with IDDM in all populations studied so far, but further population studies in non-Caucasian populations should be performed. In Caucasians, HLA-Dw2 renders protection against IDDM while HLA-Dw3 and Dw4 are associated with susceptibility to IDDM. The exact mode of inheritance of susceptibility to IDDM remains to be established. Involvement of at least two genes is likely. Heterogeneity of IDDM is highly possible and should be a matter of major interest in diabetes research.
Insulin dependent diabetes mellitus epidemiology: HLA genotype study in 12 north eastern Italian families with two siblings affected by type I diabetes
Anti-tubulin antibodies in recent onset type 1 (insulin-dependent) diabetes mellitus: comparison with islet cell antibodies
A minor subset of HLA-DR3 haplotypes is preferentially increased in type 1 (insulin-dependent) diabetes
HLA gene and phenotype data of 60 insulin-dependent diabetic patients from north-eastern Italy. A negative association with DR5 rather than DR2?
Age-related association of insulin-dependent diabetes mellitus with BfF1 and the HLA-B18, BfF1 haplotype
HLA-DR4 in insulin-dependent diabetic parents and their diabetic offspring: a clue to dominant inheritance
Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex
Distribution of HLA class II alleles among Scandinavian patients with systemic lupus erythematosus (SLE): an increased risk of SLE among non[DRB1*03,DQA1*0501,DQB1*0201] class II homozygotes?
A two-susceptibility-allele model for genetic diseases and associated marker loci: differences and similarities to a one-s-allele model
HLA-DR typing in identical twins with insulin-dependent diabetes: difference between concordant and discordant pairs
Linkage analysis between the major histocompatibility system and insulin-dependent diabetes in families with patients in two consecutive generations
Epidemiological studies of diabetes mellitus in Denmark: 3. Clinical characteristics and incidence of diabetes among males aged 0 to 19 years
Incidence and differences in urban-rural seasonal variation of type 1 (insulin-dependent) diabetes in Wisconsin
Mortality of type 1 (insulin-dependent) diabetes mellitus in Denmark: a study of relative mortality in 2930 Danish type 1 diabetic patients diagnosed from 1933 to 1972
Mutagenesis and expression of putative class II susceptibility genes: a "reverse immunogenetics" approach to analysis of HLA and disease
Contrasting features of insulin dependent diabetes mellitus associated with neuroectodermal defects and classical insulin dependent diabetes mellitus
American Diabetes Association Journals
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