Studies of the human testis. XVIII. Simultaneous measurement of nine intratesticular steroids: evidence for reduced mitochondrial function in testis of elderly men

The Journal of Clinical Endocrinology and Metabolism
J TakahashiP Troen

Abstract

To determine the basis for the decline in testosterone production by the aged testis, intratesticular unconjugated steroids, including testosterone, pregnenolone (3 beta-hydroxy-5-pregnen-20-one), 17 alpha-hydroxypregnenolone (3 beta,17 alpha-dihydroxy-5-pregnen-20-one), dehydroepiandrosterone (3 beta-hydroxy-5-androsten-17-one), androstenediol (5-androstene-3 beta,17 beta-diol), progesterone, 17 alpha-hydroxyprogesterone, androstenedione (4-androstene-3,17-dione), and 17 beta-estradiol, were measured by simultaneous RIAs in 32 previously untreated elderly men (aged 61-85 yr) undergoing orchiectomy as therapy for prostatic carcinoma and 20 young men (aged 25-35 yr) with oligospermia and varicocele. In vitro steroidogenesis using labeled pregnenolone as substrate was also investigated. Serum and intratesticular testosterone levels were lower (P less than 0.05) in aged patients [3.3 +/- 1.9 ng/ml and 0.86 +/- 0.53 microgram/g tissue (mean +/- SD)] than in young men (6.4 +/- 1.9 ng/ml and 1.7 +/- 1.1 microgram/g tissue), while circulating LH levels were higher (P less than 0.05) in elderly men (151 +/- 105 ng/ml) than in the young men (79 +/- 33 ng/ml), indicating that a primary pathological process affects the senescent testis, p...Continue Reading

Citations

May 1, 1986·Journal of Steroid Biochemistry·A Vermeulen, J P Deslypere
Feb 1, 1990·Journal of Steroid Biochemistry·K Nahoul, M Roger
Feb 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·J C HoschoianJ A Andrada
Sep 9, 2000·Experimental Gerontology·E PlasH Pflüger
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·J L Tenover
Oct 6, 1999·International Journal of Andrology·J L Tenover
Jan 31, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alvin M Matsumoto
Apr 1, 1991·Clinical Endocrinology·P LuppaD Engelhardt
Nov 1, 1984·Acta Pathologica Japonica·S OshimaS Hatakeyama
Oct 1, 1986·The Journal of Clinical Investigation·S J Winters, P Troen
Dec 9, 2008·Molecular and Cellular Endocrinology·Antti Perheentupa, Ilpo Huhtaniemi
Feb 1, 1994·Metabolism: Clinical and Experimental·H S PaulS J Winters
Nov 1, 1984·Maturitas·W Bartsch, K D Voigt
May 26, 2004·Clinics in Laboratory Medicine·Ronald J Elin, Stephen J Winters
Feb 6, 2014·Longevity & Healthspan·Michael C Velarde
Jan 4, 2007·The Journal of Pathology·N SampsonP Berger
Apr 25, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joana SantiagoMargarida Fardilha
Apr 12, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Stephanie T Page
Mar 20, 2019·Endocrine Reviews·Jean-Marc KaufmanIlpo Tapani Huhtaniemi
Jan 21, 2021·International Journal of Molecular Sciences·Markéta ŠimkováRichard Hampl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.