Studies of the mechanism of the in-loop synthesis of radiopharmaceuticals

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Andrei R StudenovKenneth R Buckley

Abstract

A series of experiments were performed to better understand the mechanism of the In-loop [11C]CH3I-methylation. The timing of [11C]CH3I delivery is critical for the high yield of radiolabeling since in-loop radioactivity trapping is reversible. Trapped radioactivity escapes faster from a Tefzel loop compared to a PEEK- or stainless steel loop. Up to 50% of delivered radioactivity may be concentrated at the loop origin (representing 8.1% of the total loop volume). A five-fold reduction of the reaction solvent volume and/or precursor amount may lead to a decrease of the product radiochemical yield either by lowering the in-loop radioactivity trapping or by diminishing conversion of [11C]CH3I into the product.

References

Apr 1, 1985·The International Journal of Applied Radiation and Isotopes·R F DannalsH N Wagner
Jan 1, 1986·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·C HalldinG Sedvall
Feb 1, 1997·Nuclear Medicine and Biology·D M JewettL C Lee
Nov 1, 2000·Nuclear Medicine and Biology·A A WilsonS Houle
Aug 23, 2001·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A T Klein, M Holschbach
Aug 24, 2001·Nuclear Medicine and Biology·D M Jewett

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Citations

Nov 6, 2012·Nuclear Medicine and Biology·Xia ShaoPeter J H Scott
Sep 22, 2010·Advanced Drug Delivery Reviews·Zibo Li, Peter S Conti
Nov 7, 2008·Angewandte Chemie·Philip W MillerAntony D Gee

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