PMID: 6103734Jun 9, 1980Paper

Studies of the neural mechanisms by which hypothyroidism decreases prolactin secretion in the rat

Brain Research
G JahnkeJ S Kizer

Abstract

These studies report that chronic hypothyroidism in the rat is accompanied by decreased serum prolactin. An investigation of those mechanisms by which hypothyroidism decreases prolactin secretion revealed the following findings: (1) activation of tyrosine hydroxylase in the median eminence (ME) and increase in the turnover-rate of dopamine (DA) in the ME; (2) a decreased content and in vitro release of prolactin by pituitaries from hypothyroid rats; (3) decreased [3H]spiroperidol binding to pituitary homogenates obtained from hypothyroid rats, and (4) normal increase of serum prolactin following administration of haloperidol. Comparison of the effects of hypothyroidism on dopaminergic terminals of the striatum with those of the ME was made and the following tentative conclusions proposed. Hypothyroidism presumably increases the release of DA into the pituitary portal system. A deficiency of thyroid hormone desensitizes the pituitary lactrotrope to inhibition by DA, decreases the total pituitary prolactin content and presumable also reduces the peripheral catabolism of prolactin. The overall net effect of hypothyroidism is, therefore, a decrease in serum prolactin levels which can increase normally following haloperidol. The mec...Continue Reading

References

Jan 11, 1979·Nature·J W Kebabian, D B Calne
Feb 1, 1979·Endocrinology·O M CramerJ C Porter
Dec 15, 1977·European Journal of Pharmacology·I CreeseS H Snyder
Jul 1, 1973·Journal of Neurochemistry·J T Coyle, D Henry
Aug 30, 1974·Nature·G KunosM Nickerson
Mar 1, 1973·The Journal of Clinical Endocrinology and Metabolism·S S StofferG M Pikler

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Citations

Jan 1, 1989·Progress in Neurobiology·N Ben-JonathanJ F Hyde
Nov 1, 1982·Molecular and Cellular Endocrinology·G Barbanel, I Assenmacher
Feb 27, 2004·European Journal of Pharmacology·Minoru HatsutaHiroshi Kogo
Jan 13, 1998·Molecular and Cellular Endocrinology·H YamanouchiM Shiino
Mar 10, 2004·The Journal of Reproduction and Development·Atsushi Tohei
Aug 1, 1995·Archives of Physiology and Biochemistry·A L MaiaN Iazigi
Jun 1, 1982·Metabolism: Clinical and Experimental·N A CataldoE C Ridgway
Jan 1, 1988·Annals of the New York Academy of Sciences·S Reichlin
May 17, 2018·Biology of Reproduction·Juneo F SilvaRogéria Serakides

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