PMID: 7940142May 1, 1994Paper

Studies of the ocular pulse in primates

Survey of Ophthalmology
T W MittagS Podos

Abstract

Ocular pulse amplitude (OPA) and intraocular pressure (IOP) were measured in groups of human subjects with primary open-angle glaucoma (POAG), ocular hypertension (OHT), low-tension glaucoma (LTG), retinal degenerations (RD), in OHT volunteers treated with single doses of 2% epinephrine, 4% pilocarpine, 0.5% timolol or 1% p-amino-clonidine, and in normal subjects before and after exercise. Compared to normal controls, OHT subjects showed significantly higher IOP and OPA, while OPA was significantly lower in ocular normotensive LTG and RD subjects groups. All drug treatments lowered IOP in OHT subjects, but did not change OPA significantly. Exercise in normal volunteers increased calculated ocular perfusion pressure by 22.5%, lowered IOP by 32%, but showed no significant change in OPA. When IOP was elevated > or = 5 mmHg in lasered monkey eyes peak pulse volume (PPV) was increased significantly in the unlasered eyes. Epinephrine 2% or 1% p-aminoclonidine lowered IOP moderately with no change in PPV, while treatment with 4% pilocarpine or 0.5% timolol reduced IOP and increased PPV significantly. The findings suggest that LTG may be associated with an ocular vascular abnormality. OPA in OHT or normal human subjects did not change ...Continue Reading

References

Aug 1, 1991·The British Journal of Ophthalmology·C B James, S E Smith
Feb 1, 1991·Experimental Eye Research·M E LanghamM Sebag
Sep 1, 1965·Experimental Eye Research·C A Paterson, M E Paterson

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Citations

Sep 28, 2004·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·K-G Schmidt
Jan 15, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Chantal VulstekeThierry Zeyen
Jan 17, 2013·Japanese Journal of Ophthalmology·Chihiro Mayama, Makoto Araie
Sep 25, 2010·Revista brasileira de anestesiologia·Catia Sousa Govêia, Edno Magalhães
Oct 25, 2003·Progress in Retinal and Eye Research·Vital P CostaLuis Metzner Serra
Jun 1, 1997·American Journal of Ophthalmology·V Hessemer, K G Schmidt
May 18, 2010·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Daniela Sonja NoschOliver M Stuhrmann
Jun 17, 2003·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Emma L PriceNorman F Button
Jan 8, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Fabrice GogniatMichael Goldschmidt
Feb 1, 2017·Acta Ophthalmologica·Karin R PillunatLutz E Pillunat

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