Jun 1, 1981

Studies of the renal vasoactive systems in hyporeninemic hypoaldosteronism

Prostaglandins and Medicine
J HahnR Horton


Plasma renin activity, total renin, active renin, and aldosterone were measured as well as urinary prostaglandin E2 and kallikrein in a group of patients with hyperkalemia (6.1-7.7 mEq per liter) and hyporeninemic hypoaldosteronism. Plasma renin activity and aldosterone were low and the response was markedly blunted to upright posture, and furosemide. The rise in cortisol but not aldosterone was normal following ACTH stimulation. Active renin was depressed; however, total renin was normal. Urine PGE was variable including some low values, but the mean of the group was normal (p greater than 0.1). Urine kallikrein excretion was markedly diminished and undetectable in most cases. Fludrocortisone normalized potassium but minimally increased kallikrein in the patients. The possibility exists that kallikrein deficiency in these patients may underlie the inability to generate active renin.

  • References12
  • Citations2


  • References12
  • Citations2

Mentioned in this Paper

Aldosterone Measurement
Depressed - Symptom
POMC wt Allele
Hypoaldosteronism, Hyporeninemic
Salix - substance
Prostaglandin E2 Measurement

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