PMID: 6407346May 1, 1983Paper

Studies of Trypanosoma cruzi clones in inbred mice. I. A comparison of the course of infection of C3H/HEN- mice with two clones isolated from a common source

The American Journal of Tropical Medicine and Hygiene
M PostanJ P McDaniel

Abstract

Two single-cell-isolate cloned stocks of the Sylvio-X10 strain, recovered from an acute human Trypanosoma cruzi infection, were used to infect C3H/HEN mice. The Sylvio-X10/4 clone produced a chronic infection in mice; clone Sylvio-X10/7 produced an acute lethal infection under identical experimental conditions. The course of infection of mice with the Sylvio-X10/7 clone was characterized by higher peripheral blood parasitemia and greater tissue involvement, an earlier appearance of specific anti-T. cruzi plasma IgG and shorter survival times than in mice infected with the Sylvio-X10/4 clone. The course of infection in mice with the Sylvio-X10 strain was intermediate between that of the two clones. This is the first demonstration of the pluripotential pathogenetic nature of a T. cruzi strain due to genetic heterogeneity of the population of parasites that constitute the strain. This experimental system is highly stable and reproducible. Consequently, the use of inbred mice and T. cruzi clones appears to provide an excellent model to study factors which influence the course of Chagas' disease.

Citations

Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·M PostanJ A Dvorak
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·M PostanJ A Dvorak
Oct 1, 1994·Revista Da Sociedade Brasileira De Medicina Tropical·J P Marretto, S G Andrade
Mar 1, 1996·Memórias do Instituto Oswaldo Cruz·M M de SouzaZ A Andrade
Jan 1, 1996·Revista Da Sociedade Brasileira De Medicina Tropical·S G Andrade, J B Magalhães
Jan 31, 2009·Infection and Immunity·Craig Weinkauf, Mercio Pereiraperrin
Mar 17, 2011·PLoS Neglected Tropical Diseases·Oscar FranzénBjörn Andersson
Apr 10, 2020·Cellular Microbiology·Matías Exequiel RodríguezValeria Tekiel
Aug 1, 1985·Annals of Tropical Medicine and Parasitology·S G AndradeM B Netto
Nov 1, 1987·The Journal of protozoology·R W Finley, J A Dvorak
Jan 1, 1991·Parasitology Research·M T LimaC R Gattass
Jan 28, 1999·Memórias do Instituto Oswaldo Cruz·V T ContrerasG Zorrilla
May 1, 1997·Revista Da Sociedade Brasileira De Medicina Tropical·L Lauria-PiresA R Teixeira
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·M PostanJ P McDaniel
Sep 6, 2018·PloS One·Luz P Quebrada PalacioMiriam Postan
Aug 18, 2020·Parasite Immunology·Damián Pérez-MazliahMichael D Lewis
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·A O LuquettiI Rodrigues
Sep 14, 2004·Immunological Reviews·Diana Martin, Rick Tarleton
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·R L TarletonM O Downs
May 1, 1984·The Journal of protozoology·P S DoyleJ C Engel
Feb 10, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N V VerbisckR A Mortara
Dec 6, 2007·Memórias do Instituto Oswaldo Cruz·José Rodrigues Coura
Oct 20, 2017·Frontiers in Cellular and Infection Microbiology·Carla A PascualeM Susana Leguizamón
Jul 27, 2011·Infection and Immunity·Craig WeinkaufMercio Pereiraperrin
Aug 1, 1986·Infection and Immunity·R A WrightsmanJ E Manning
Oct 1, 1990·Infection and Immunity·W Wagner, M So
Jul 17, 2003·International Journal for Parasitology·Takeshi NaraTakashi Aoki

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