PMID: 6171218Nov 1, 1981Paper

Studies on a circulating anticoagulant in procainamide-induced lupus erythematosus

Archives of Internal Medicine
R L EdwardsC J Wakem

Abstract

Circulating anticoagulant activity that had at least two distinct mechanisms--one directed against factor XII and one directed against blood thromboplastin (prothrombin activator complex)--developed in a patient with clinical and laboratory evidence of procainamide hydrochloride-induced systemic lupus erythematosus. The anticoagulant activity behaved as a gamma-globulin in chromatographic and electrophoretic analyses, with the majority of activity behaving as an IgM immunoglobulin. Despite markedly abnormal coagulation study results, no clinical bleeding occurred. Anticoagulant activity paralleled clinical and laboratory evidence of the inflammatory disease and improved on discontinuance of procainamide therapy.

Citations

Dec 14, 2011·Current Rheumatology Reports·Jeffrey S Dlott, Robert A S Roubey
Jun 1, 1987·Journal of Neurology·V L Babikian, J D Levine
Jan 1, 1984·Stroke; a Journal of Cerebral Circulation·R G HartV Bril

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