Studies on a toxic metabolite from the mould Wallemia

Food Additives and Contaminants
G M WoodM O Moss

Abstract

While monitoring the occurrence of toxigenic moulds in foods, using a bioassay screen, it was shown that an isolate of Wallemia sebi produced toxic effects in several of the bioassays. The toxic metabolite was isolated and purified using solvent extraction, TLC and HPLC coupled with the brine shrimp assay to monitor the toxic fractions. The purified toxin, which we propose to call walleminol A, has been partially characterized by mass spectroscopy, nuclear magnetic resonance, ultraviolet and infrared spectroscopy. It can be provisionally interpreted as a tricyclic dihydroxy compound, C15H24O2, with structural features characteristic of a sesquiterpene with an isolated double bond, but further work is required to characterize this compound unequivocally. The minimum inhibitory dose of walleminol A in the bioassays is approximately 50 micrograms/ml, which is comparable with a number of mycotoxins such as citrinin and penicillic acid.

References

Jul 1, 1977·Journal of General Microbiology·J I Pitt, A D Hocking
Feb 1, 1974·The Australian and New Zealand Journal of Surgery·C Flanc, J Syme
Jan 30, 1981·Mycopathologia·H HitokotoH Kurata
Mar 1, 1980·Applied and Environmental Microbiology·A D Hocking, J I Pitt

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Citations

Sep 8, 2001·International Journal of Food Microbiology·A PatriarcaR Comerio
Feb 15, 2002·International Journal of Food Microbiology·J VytrasováL Marvanová
Dec 3, 2004·Applied and Environmental Microbiology·Qing-Yin ZengXiao-Ru Wang
Jan 5, 2008·Journal of Clinical Microbiology·Josep GuarroShalini Kakkar
Nov 5, 2014·Applied Microbiology and Biotechnology·J David Miller, David R McMullin
May 29, 2015·PloS One·Sašo JančičNina Gunde-Cimerman
Aug 31, 2017·Extremophiles : Life Under Extreme Conditions·Jorge R Díaz-ValderramaM Catherine Aime

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