Studies on acute myelomonocytic leukemia in LBF1 rats

Cancer Letters
L KozmaPal Kertai

Abstract

Granulocytic leukemia was induced in Long-Evans (LE) rats by using the Huggins and Sugiyama method. After serial passage the cells became transformed. The newly transformed cells could be transplanted to LBF1 hybrid rats and observed more readily. A quantity of 10(8) cells/100 g body weight was injected intravenously and after 2-3 weeks myelomonocytic leukemia developed. By examining the bone marrow, spleen and lymph nodes, cytochemical tests verified this transformation. Transplanting 10(2)-10(4) cells under the renal capsule, a quickly growing solid tumor was observed, which caused metastasis to the parathymical lymph nodes and peritoneum. The investigation of oncogene expression for the myc and ras families revealed the presence of myc p62 and ras p21 oncoproteins in the tumor cells by using monoclonal antibodies in immunohistochemical tests. LBF1 rats proved to be good models in obtaining solid tumor growth and myelomonocytic leukemias, equivalent to human M4-M5 type leukemia.

References

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Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D A Spandidos
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Nov 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L S KAPLOW, M S BURSTONE

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Citations

Sep 29, 2011·DNA and Cell Biology·Gyorgy TrencsenyiGaspar Banfalvi
Mar 19, 2014·Leukemia Research·G TrencsenyiG Banfalvi
Feb 13, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Gyorgy TrencsenyiGaspar Banfalvi
Jul 16, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cristina A DeheleanFlavia Baderca
Nov 30, 2004·Expert Opinion on Investigational Drugs·Michael J Strong
Aug 30, 2008·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Michael J Strong
May 23, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Michael J StrongDenise Figlewicz

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