Studies on agents with vasodilator and beta-blocking activities. IV

Chemical & Pharmaceutical Bulletin
T SekiK Yasuda

Abstract

A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and beta-blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Among them, the 5-chloro-2-cyanophenoxy derivative (29) showed the promising dual activities and was selected for further studies.

Citations

Nov 1, 2012·North American Journal of Medical Sciences·Mohammad Asif
Oct 21, 2016·Organic & Biomolecular Chemistry·Nicolás GrimblatSebastian O Simonetti
Dec 14, 2004·The Journal of Biological Chemistry·Jianxin HuAllen M Spiegel
Feb 19, 2004·Archives of Pharmacal Research·Seref DemirayakBasar Sirmagul
Jul 20, 2002·The Journal of Organic Chemistry·Jeffrey J PosakonyTimothy J Tewson

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