Studies on alterations in blood coagulative and fibrinolytic activities after single and multiple administrations of carbon tetrachloride in mice

Japanese Journal of Pharmacology
M OkazakiK Sakamoto

Abstract

The time course of alterations in coagulative and fiblinolytic activities was studied in CCl4-induced liver disease in mice. Liver disease was induced by administration of 20% CCl4 in olive oil (p.o.). After single administration of CCl4, significant prolongation of r and k values and decrease in the ma value of thromboelastogram and apparent prolongation of PT and PTT were seen at 24 hr. Fibrinogen content decreased from 12 to 72 hr after single administration, while a mild but significant decrease in fibrinogen was observed after multiple administrations. The activity of factor XIII increased from 5 to 12 hr and then decreased from 24 to 168 hr after single administration. The activity of the hepaplastintest and Antithrombin III decreased apparently after single and multiple administrations. The plasminogen content and the activity of alpha 2-plasmin inhibitor decreased severely after single and multiple administrations. These results indicate that the coagulative and fibrinolytic activities were decreased to the most lowest value at 24 or 48 hr after single administration of CCl4, and the severe suppression of fibrinolysis and the mild decrease in coagulative activity were observed after multiple administrations of CCl4. The...Continue Reading

References

Jan 1, 1979·Progress in Cardiovascular Diseases·N Aoki
Nov 1, 1972·Plastic and Reconstructive Surgery·H E Koehnlein
Nov 1, 1969·American Journal of Clinical Pathology·E E Mandel, W M Gerhold
Nov 17, 1980·Biochemical and Biophysical Research Communications·W NieuwenhuizenD van der Heide
Jan 1, 1963·The Journal of Clinical Investigation·P W STRAUB

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Citations

Jan 1, 1997·Journal of Atherosclerosis and Thrombosis·M OkazakiK Oguchi

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