Studies on antibody to intrinsic factor

The Journal of Clinical Investigation
S G SchadeR F Schilling

Abstract

Sera from a group of 79 patients with pernicious anemia were studied for the presence of antibody to intrinsic factor. Two general types of antibody activity were found, and it was possible to distinguish three groups of pernicious anemia sera on the basis of their content of these types. Type I antibody blocks the binding of radioactive vitamin B(12) to intrinsic factor when added to intrinsic factor before the B(12); it is not detected on intrinsic factor when added after B(12). This antibody blocks intrinsic factor-mediated B(12) absorption in vivo when mixed in the sequence intrinsic factor + antibody I + B(12), but not when mixed in the sequence intrinsic factor + B(12) + antibody I. Type II antibody reacts with intrinsic factor when B(12) is attached. This antibody prevents the absorption of B(12) from intrinsic factor in pernicious anemia patients when mixed in the sequence intrinsic factor + B(12) + antibody II, and is thereby distinguished from antibody I.

Citations

Feb 20, 1993·Biochimica Et Biophysica Acta·N LiB Seetharam
Jul 1, 1987·Baillière's Clinical Gastroenterology·M D Kaye
Dec 28, 1967·The New England Journal of Medicine·G M Bernier, J D Hines
Aug 22, 1968·The New England Journal of Medicine
Jan 1, 1971·British Journal of Haematology·J M Fisher, K B Taylor
Oct 1, 1989·Journal of Clinical Pathology·R J DavidsonH F Sewell
Mar 1, 1969·The Journal of Clinical Investigation·I L MackenzieR F Schilling
Jan 1, 1985·Critical Reviews in Oncology/hematology·Y KanoF Takaku
May 1, 1970·The American Journal of Medicine·W B Castle
Jan 13, 1968·Lancet·K D BardhanS T Callender
May 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation·J ArnaudG Ville
Sep 1, 1967·Journal of Clinical Pathology·K D BardhanS T Callender
Jan 20, 1970·Biochimica Et Biophysica Acta·A E FinklerC A Hall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Clinical Investigation
G H JeffriesM H Sleisenger
The New England Journal of Medicine
W J IRVINE
Clinica Chimica Acta; International Journal of Clinical Chemistry
H A ShepherdD P Jewell
The Journal of Clinical Investigation
M E KAPLANV HERBERT
© 2021 Meta ULC. All rights reserved