PMID: 14247731Nov 1, 1964Paper


The Journal of Experimental Medicine
B B LEVINE, B Benacerraf


The enzymatic degradation of fluorescein conjugates of poly-L-lysine, poly-D-lysine, and exhaustively succinylated poly-L-lysine by aqueous extracts of spleens from "responder" (guinea pigs which can develop immune responses to hapten-poly-L-lysine conjugates) and "non-responder" guinea pigs was investigated. The in vivo degradation of H(3)-tagged dinitrophenyl conjugates of these synthetic polyamino acids was also studied by measuring urinary excretion of radioactive low molecular weight degradation products of these conjugates after their intraperitoneal injection. It was found that both responder and non-responder guinea pigs can degrade succinylated and unsuccinylated poly-L-lysine conjugates into small molecular fragments, but they cannot degrade hapten-poly-D-lysine conjugates. These studies demonstrate that in addition to the known requirements for antigenicity of macromolecules, i.e. the presence of antigenic determinants, and their capacity to be degraded by immunological tissues, the resulting degradation products must undergo certain additional, as yet unidentified, specific metabolic steps in order to induce an immune response.


Nov 28, 2012·Amino Acids·Karen S JacksonChongsuk Ryou
Jul 1, 1975·Immunochemistry·L Yuan
Nov 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·I GreenB Benacerraf
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R K GershonC F Merryman
Jan 1, 1974·Transplantation Reviews·W W Bullock, E Möller
Jan 1, 1978·Immunological Reviews·B Benacerraf, R N Germain
Mar 1, 1970·Angewandte Chemie·E Rüde
Aug 1, 1965·Biochemistry·S F SchlossmanH A Sober
Apr 5, 1969·Nature·C Collotti, S Leskowitz
Mar 5, 1979·Molecular and Cellular Biochemistry·J S Garvey, E B Reilly
Dec 3, 1973·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·H Metzke, E M Broesan
Oct 15, 1969·Klinische Wochenschrift·H Huber, H H Fudenberg
Dec 12, 1969·Science·M Sela
Mar 1, 1969·The Journal of Investigative Dermatology·L Polák, J L Turk

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