Studies on bioactive saponins from Chinese medicinal plants

Advances in Experimental Medicine and Biology
R S XuG Qin

Abstract

In our recent studies on bioactive saponins, two Chinese medicinal plants: Mussaenda pubescens Ait.f (Rubiaceae) and Clematis chinensis Osbeck (Ranunculaceae), were investigated. Of the two medicinal plants, M. pubescens is a Chinese folk medicine which has been used as a diuretic, antiphlogistic, diaphoretic and antipyretic agent, and has also been used to detoxify mushroom poisons and to terminate early pregnancy. Clematis chinensis is a Chinese traditional medicine which has been used as an analgesic, diuretic, antitumor, antiinflammatory and insecticidal agent for ages. As a result of our studies, eighteen saponins were identified from M. pubescens, among which seventeen were new compounds, while eleven saponins were isolated from C. chinensis, three of which were new compounds. In the course of our structural studies, mass fragment analysis in FAB-mass spectra and 1H- and 13C-NMR spectra were used to determine the structures of the sapogenin and oligosaccharide moieties. In those more complicated and minor saponins, various 2D-NMR experiments were carried out on 400-, 500- or 600-MHz NMR instruments, which permitted the identification of new sapogenins in glycoside form. In addition, it was also possible to assign all the ...Continue Reading

Citations

Jun 15, 2019·International Journal of Microbiology·Manikkuwadura Hasara Nethmini De ZoysaWeerasinghe Mudiyanselage Dilip Gaya Bandara Wijayaratne
May 13, 2014·BioMed Research International·Ma Ma LaySri Nurestri Abd Malek
Jun 9, 2009·Journal of Asian Natural Products Research·Li-Fang LiuQiu-Ling Tang
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daria GrzywaczHenryk Myszka

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