Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction, Fe and rhEPO based on colon cancer-related anemia model and gut microbiota modulation.

Chinese Journal of Natural Medicines
Xu-Qin ShiJin-Ao Duan

Abstract

Colon cancer-related anemia (CCRA) is mainly caused by systemic inflammation, intestinal bleeding, iron deficiency and chemotherapy-induced myelosuppression in colon cancer. However, the best therapeutic schedule and related mechanism on CCRA were still uncertain. Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction (DBD), Fe and rhEPO based on CCRA and gut microbiota modulation were conducted in this paper. Here, CCRA model was successfully induced by subcutaneous inoculation of CT-26 and i.p. oxaliplatin, rhEPO + DBD high dosage + Fe (EDF) and rhEPO + DBD high dosage (ED) groups had the best blood enrichment effect. Attractively, EDF group also showed antitumor activity. The sequencing results of gut microbiota showed that compared to P group, the relative abundances of Lachnospiraceae and opportunistic pathogen (Odoribacter) in ED and EDF groups were decreased. Interestingly, EDF also decreased the relative abundances of cancer-related bacteria (Helicobacter, Lactococcus, Alloprevotella) and imbalance-inducing bacteria (Escherichia-Shigella and Parabacteroides) and increased the relative abundances of butyrate-producing bacteria (Ruminococcaceae_UCG-014), however, ED showed the opposite effe...Continue Reading

References

Dec 14, 2002·FEMS Microbiology Letters·Susan E PrydeHarry J Flint
Sep 30, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tomoko AkaseShin-ichi Tashiro
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
May 8, 2010·The British Journal of Nutrition·Ramadass BalamuruganBalakrishnan S Ramakrishna
Jun 15, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Duong H NguyenAladar A Szalay
Aug 6, 2013·FEMS Microbiology Ecology·Karen P ScottHarry J Flint
Sep 26, 2013·Methods in Enzymology·José A Navas-MolinaRob Knight
Jul 27, 2015·Trends in Biotechnology·Na-Ri ShinJin-Woo Bae
Nov 19, 2015·MBio·Alexandra DostalChristophe Chassard
Dec 24, 2015·International Journal of Colorectal Disease·José Luis CallejaUNKNOWN Colon Cancer Study Group
Apr 8, 2016·Current Opinion in Supportive and Palliative Care·Ronwyn van Eeden, Bernardo L Rapoport
Jul 12, 2017·Ecology and Evolution·Carlo Ricotta
Oct 27, 2017·The American Journal of Clinical Nutrition·Daniela Paganini, Michael B Zimmermann
Feb 16, 2018·BioMed Research International·Peng BinXihong Zhou
Oct 12, 2018·Pharmaceuticals·Bahtiyar Yilmaz, Hai Li
Sep 22, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shi-Jun YueYu-Ping Tang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.