Studies on bone marrow histogenesis: morphometric and autoradiographic studies of regeneration marrow stroma in extramedullary autoimplants and after evacuation of marrow cavity

Cell and Tissue Research
H A Sahebekhtiari, M Tavassoli

Abstract

The marrow cavity of the rat tibia was mechanically evacuated and autoimplanted to the subcutaneous tissue. The regenerative process which restored the integrity of marrow stroma and hemopoiesis, was morphometrically evaluated in whole mount of tibia. Following evacuation, the clot filled the cavity. The granulation tissue then appeared and expanded, penetrating and replacing the clot. The fibroblasts of the granulation tissue differentiated into osteoblasts forming osteoid bone. Within its interstices, the primordial marrow consisting of loose connective tissue and vascular sinuses appeared and hemopoiesis resumed. Expansion of hemopoiesis resulted in the resorption of bone and within three weeks the tibial cavity was restored to the pre-evacuation state. Autoradiography indicated that the labeling index was initially high in fibroblasts and osteoblasts but was subsequently reduced while it increased in osteocytes, cells of Haversian canals, stromal and hemopoietic cells of marrow. The finding is in disagreement with the view that the regenerative process originates from the Haversian canal. When the label was introduced on day 4 post-operatively, it subsequently appeared in osteocytes, cells of Haversian canal, stromal elemen...Continue Reading

Citations

Mar 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R ZhangD J Simmons
Apr 1, 1995·Calcified Tissue International·R W ZhangD J Simmons
Mar 22, 2014·Annals of the New York Academy of Sciences·Erica L Scheller, Clifford J Rosen
Jun 1, 2014·The Journal of Clinical Endocrinology and Metabolism·Margaret C GarinAnne R Cappola
Dec 14, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tanja SikjaerLeif Mosekilde
Sep 10, 2003·Orthodontics & Craniofacial Research·C Verna, B Melsen

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