PMID: 46155Jan 24, 1975

Studies on brain-thymus cross-reactive antigens

Brain Research
G Birnbaum

Abstract

An antigen(s) shared by mouse brain and thymocytes was studied with the use of a rabbit anti-mouse brain antiserum (RAMB). Full complements of brain-thymus antigen were found on the brains of several mouse strains, including athymic mice, regardless of their theta antigen genotype. Brain-thymus antigen(s) was absent in newborn mouse brains and gradually reached adult levels two weeks after birth. Treatment of mouse brain with trypsin neither decreased nor increased the amount of the brain-thymus antigen available for absorption of RAMB. Mouse brain-thymus antigens were present on rat thymocytes, but not rat brain. The concentrations of brain-thymus antigens were 3- to 4-fold higher in gray matter than white matter. Cross-absorption studies with RAMB and anti-theta antiserum suggest that theta antigen and brain-thymus antigen are two distinct substances, both antigenically and in their anatomical localization on brain cells.

References

Sep 28, 1973·Brain Research·M Schachner, R L Sidman
Jan 1, 1974·Transplantation·C H ChenA H Sehon
Apr 1, 1972·The Journal of Experimental Medicine·M ScheidL J Old
Apr 1, 1973·Cellular Immunology·M I Gyöngyössy, J H Playfair
Oct 1, 1969·Experimental Neurology·A La Velle, P J Van Alten
Apr 1, 1971·Journal of Neurochemistry·H R HerschmanJ De Vellis
Aug 1, 1972·The Journal of Experimental Medicine·E S Golub
Jun 1, 1970·The Journal of Experimental Medicine·T TakahashiE A Boyse
Jan 29, 1966·Nature·A E REIF, J M ALLEN
Sep 1, 1964·The Journal of Experimental Medicine·A E REIF, J M ALLEN

Citations

Jun 1, 1976·Biulleten' eksperimental'noĭ biologii i meditsiny·G A Belokrylov, I L Zhitnukhin
Apr 1, 1980·Biulleten' eksperimental'noĭ biologii i meditsiny·A G Artemova
Aug 1, 1980·Biulleten' eksperimental'noĭ biologii i meditsiny·G A Belokrylov, B N Sofronov
Feb 6, 2008·Zebrafish·Alexander ReuterClaudia A O Stuermer
Jan 1, 1977·Scandinavian Journal of Immunology·B D JankovićM Mostarica
Jun 1, 1982·Journal of Neurochemistry·P J RichardsonV P Whittaker
Jan 1, 1982·Immunological Communications·V Wicher, C Amesty
Jun 1, 1979·European Journal of Immunology·F S BaechtelE S Vitetta
Dec 1, 1991·DICP : the Annals of Pharmacotherapy·W D Figg
Jun 1, 1992·The Annals of Pharmacotherapy·J S Marinac

Related Concepts

Antigenic Specificity
Antigens
Brain
Plasma Membrane
Cross Reactions
Microcytotoxicity Test
Immune Sera
Mice, Inbred Strains
T-Lymphocyte
Thymus Gland

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