Studies on calcium oxalate monohydrate crystallization: influence of inhibitors

Urological Research
F GrasesA Costa-Bauzá

Abstract

A simple model to study calcium oxalate monohydrate (COM) crystallization on different substrates is presented and the action of different potential inhibitors is evaluated and discussed. COM heterogeneous nucleation was assayed on solid surfaces as calcium phosphate, mixtures of mucin with calcium phosphate, and wax. In the presence of a non-protected non-renewed solid surface in contact with normal urine, COM crystal formation could be detected at short intervals (3 h). The most active heterogeneous nucleation capacity corresponded to calcium phosphate. In the presence of 10% mucin, owing to the renewal of the surface layer no COM crystal were detected on the pellet's surface. The study of citrate and pentosan polysulphate (a semisynthetic polysaccharide) on COM heterogeneous nucleation demonstrated some important inhibitory effects when concentration increased and time decreased. Maximum effects were selectively manifested on calcium phosphate surfaces. Only phytic acid at adequate concentration exhibited a total inhibitory capacity of COM formation, even during longer intervals (15 h).

References

Sep 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·F L CoeV Tembe
May 1, 1978·Kidney International·B Finlayson
Sep 1, 1992·British Journal of Urology·F GrasesA Costa-Bauzá
Sep 1, 1990·British Journal of Urology·F Grases, A Costa-Bauzá
Jan 1, 1991·Urological Research·F GrasesL Masárová
Jan 1, 1993·Nephron·O Söhnel, F Grases

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Citations

Jan 1, 1995·International Urology and Nephrology·F GrasesA Costa-Bauzá
May 20, 2011·Urological Research·F GrasesR M Prieto
Oct 1, 1996·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·F HarangiB Melegh
Jul 12, 2005·Annual Review of Biomedical Engineering·James D WeilandMark S Humayun
Jun 1, 2012·ACM Journal on Emerging Technologies in Computing Systems·Wen H Ko
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Felix Grases, Antonia Costa-Bauza

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