PMID: 1193455Jan 1, 1975Paper

Studies on catabolism of 125I-labelled fibrinogen in normal rabbits and in rabbits with indwelling intravenous catheters: methodologic aspects

Haemostasis
I Mahn, G Müller-Berghaus

Abstract

The catabolism of rabbit fibrinogen labelled with radioactive iodine was studied over a period of 7-9 days in normal rabbits and in rabbits with indwelling intravenous catheters. The labelled fibrinogen was highly clottable and homogeneous on immunoelectrophoresis and disc electrophoresis. The protein-bound 125I-activity amounted to at least 99%. Normal rabbits with a weight between 1.6 and 2.2 kg exhibited a mean plasma volume of 41.65 ml/kg. A mean half-life time of 1.69 days and a mean fractional catabolic rate of 59.8% of the plasma fibrinogen pool per day was computed by tracing labelled fibrinogen. The absolute catabolic rate revealed a mean value of 58.7 mg/kg body weight/day. Comparable results were obtained for all three labelled fibrinogen batches. A siliconized polyvinyl tubing with an outer diameter of 2.0 mm inserted into a jugular vein up to a length of 10-12 cm and indwelling for more than 10 days did not significantly influence the parameters studied for controlling the fibrinogen catabolism except for the absolute catabolic rate of 112.8 mg/kg/day which differed significantly from that of the control group. Thus, the indwelling intravenous catheter had no or only a minor effect on the activation of intravascula...Continue Reading

Citations

Sep 1, 1996·Journal of Molecular Recognition : JMR·A Sanders, H P Jennissen
Jan 1, 1996·Journal of Clinical Apheresis·I S JovinG Müller-Berghaus
Jan 1, 1978·Journal of Immunological Methods·C Mueller-EckhardtI Mahn
Jan 1, 1981·Journal of Immunological Methods·S Bhakdi, W Kayser
May 1, 1990·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C SchubringG Müller-Berghaus
Feb 1, 1979·Thrombosis Research·W KrellG Müller-Berghaus
Jul 1, 1985·Biochimica Et Biophysica Acta·K T PreissnerG Müller-Berghaus
Mar 17, 2004·Biosensors & Bioelectronics·H P Jennissen, T Zumbrink
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·U Scheefers-BorchelN Heimburger
Jul 1, 1983·British Journal of Haematology·W KayserK Ebert
Mar 17, 1986·European Journal of Biochemistry·J RötkerG Müller-Berghaus
Jul 1, 1977·Thrombosis Research·I MahnG Müller-Berghaus
Aug 15, 1988·Thrombosis Research·H DitterE Lohmann
Jan 1, 1977·Thrombosis Research·W Kramer, G Müller-Berghaus
Mar 1, 1978·American Journal of Surgery·F W Blaisdell, C J Graziano
Mar 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·B Weimar, U Delvos
Apr 20, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Sulagna Dutta, Pallav Sengupta

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