PMID: 2512062Jun 1, 1989Paper

Studies on CFU-mix of 47 patients with leukemia and myelodysplastic syndrome

Chinese Medical Journal
Y ChenD J Yu

Abstract

By limiting dilution assay, CFU-Mix of 47 cases of untreated leukemia, myelodysplastic syndrome and 30 cases of normal adults were studied. It is suggested that most cases of acute nonlymphocytic leukemia, like chronic myelogenous leukemia (CML) and myelodysplastic syndrome should have defect in pluripotent hemopoietic stem cell. The CFU-Mix of acute myelogenous leukemia (AML) and CML were obviously lower than that of normal adults (p less than 0.001). By light microscopy, scanning and transmission electron microscopy, it was confirmed that the CFU-Mix colonies, of leukemic patients were chiefly composed of leukemic cells. Their incorporating rate of 3H-TdR was high in the early stage of culture, but that of 55 + 59Fe was low in the whole course. This phenomenon was quite different from that of the normal adults in that the CFU-Mix of the patients showed distinctive proliferation and differentiation into the leukemic progenitor cells.

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.