PMID: 6413434Oct 15, 1983Paper

Studies on chemically induced rat tumors. II. Partial protection against syngeneic lethal tumors by cloned syngeneic cytotoxic T lymphocytes

International Journal of Cancer. Journal International Du Cancer
H BinzH Wigzell

Abstract

In the present article we describe studies on a chemically induced sarcoma in DA rats. This tumor expresses a unique antigen which can be demonstrated by both syngeneic antibodies and cytotoxic T cells. We have established cytotoxic T-cell lines (CTLs) specific for the tumor and with high efficient killing capacity in vitro. When testing for the ability of such CTLs to inhibit tumor out-growth in vivo, we found that they had to be inoculated together with the tumor and in the presence of T-cell growth factor to provide any significant degree of protection. We thus believe not only that there is a requirement for addition of CTL-stimulating lymphokines in vivo, but also that the CTLs fail to move from one site in vivo to attack relevant tumor cells at another site. No evidence was obtained that the CTLs gradually could acquire such migratory ability in vivo.

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Citations

Jan 14, 1993·Journal of Immunological Methods·A Rudolphi, J Reimann
Mar 7, 2002·International Reviews of Immunology·P H BasseR B Herberman
Sep 1, 1986·Immunobiology·M A CheeverP D Greenberg
Feb 1, 1985·Immunology Today·R A Robins, R W Baldwin
Dec 15, 1986·International Journal of Cancer. Journal International Du Cancer·F NagaseT Yoshida
Oct 6, 2020·The Journal of Reproduction and Development·Junko NoguchiTadashi Furusawa

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