PMID: 702521Sep 25, 1978Paper

Studies on chloride permeability of the skin of Leptodactylus ocellatus: III. Na+ and Cl- effect on electrical phenomena

The Journal of Membrane Biology
E Rodríguez BoulanM Cereijido

Abstract

During their flux through the skin of the frog Leptodactylus ocellatus, Na+ and Cl- interact with each other. This interaction gives rise to electrical phenomena which are studied in the present paper. The skin is mounted in Na2SO4 Ringer's with 115 mM Na+ on the inside, and a variety of outer solutions. The osmolarity of all solutions is kept constant at 237.8 mosmol by adding sucrose. When the main anion used on the outside is SO=4 the electrical potential difference (deltapsi) rises steadily with the concentration of sodium (Na+)0 up to 87 mV, which is reached at about 20 mM. Thereafter deltapsi remains constant. When the main anion is Cl- it is observed that deltapsi rises steadily with (NaCl)0 with a slope similar to the curve obtained with SO=4 (37 mV per decade), but with a lower intercept attributed to an inward Cl pumping which is characteristic of this frog species. At 2--9 mM (NaCl)0 a Cl-specific channel is activated. Further increases of (NaCl)0 produce a decrease of deltapsi. The specificity of the activation of this site by monovalent cations and its use by monovalent anions is also studied.

References

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Citations

Oct 1, 1988·Pflügers Archiv : European journal of physiology·F Lacaz-Vieira, J Procopio
Aug 21, 1980·The Journal of Membrane Biology·T U BiberT L Mullen
Jun 15, 1980·The Journal of Membrane Biology·T U BiberT L Mullen
Jan 1, 1987·The Journal of Membrane Biology·E H LarsenK R Spring
Sep 30, 1980·The Journal of Membrane Biology·J Ehrenfeld, F Garcia-Romeu
Oct 1, 1986·Acta Physiologica Scandinavica·A F Harck, E H Larsen
Sep 24, 2004·Physiological Reviews·M CereijidoL Shoshani

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