Studies on chromatin. III. v-Bodies and free DNA in chromatin lacking histone H1

Molecular Biology Reports
A J Varshavsky, V V Bakayev

Abstract

Chromatin lacking histone H1 was found by electron microscopy to contain 'beaded' deoxyribonucleoprotein fibers. Adjacent beads are connected with each other by threads having a DNA-like appearance. At least some of threads are shown to be free DNA stretches. Average length and the content of free DNA stretches in histone H1-depleted chromatin depends on the ionic conditions of the medium. The appearance of individual beads is similar to that of chromatin subunits or v-bodies [1] in the original chromatin. Thus, in agreement with the X-ray data [2], histone H1 apparently is not required for maintenance of a compact state of DNA in chromatin subunits.

References

Mar 1, 1975·The Journal of Cell Biology·A L OlinsD E Olins
Jan 25, 1974·Science·A L Olins, D E Olins
Sep 20, 1974·Nature·M Noll
Jan 1, 1974·Cold Spring Harbor Symposia on Quantitative Biology·G P GeorgievR B Church
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R AxelG Felsenfeld
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H Weintraub, F Van Lente
Nov 9, 1972·Biochimica Et Biophysica Acta·A J Varshavsky, G P Georgiev
May 15, 1973·Biochemical and Biophysical Research Communications·D R Hewish, L A Burgoyne
Jun 15, 1973·European Journal of Biochemistry·L A Bolund, E W Johns
Aug 16, 1974·Nature·A J VarshavskyG P Georgiev

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Citations

Jul 1, 1976·European Journal of Biochemistry·A J VarshavskyG P Georgiev
Sep 1, 1977·Cell·A Worcel, C Benyajati

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