PMID: 107979Jan 1, 1978

Studies on composites of collagen and a synthetic polymer. Second report - mode of reaction of a laminar composite with living tissue, and results of long-term implantation

Biomaterials, Medical Devices, and Artificial Organs
Y ShimizuT Hino


We have been studying composites of synthetic polymers and proctase-treated bovine collagen (telopeptide-poor collagen). In a previous paper, it is described that one of our composites appears to have a high tissue affinity, because it was found under a scanning electron microscope, well bonding the living tissue 6 weeks after implantation in the rabbit subcutaneous tissue. In the present study, the composites were also implanted in the subcutaneous tissue in rabbits to observe the mode of its bonding to the living tissue, and at the same time the bonding force was measured at various intervals during a period of 1.5 years, to observe the degree and duration of the effect of the composition, and further to study the optimal conditions for preparation of such a composite. As a method of composition, ultraviolet radiation and glutaraldehyde treatment were also comparatively examined, besides gamma-radiation that had been employed in a previous study. As the results, it is revealed that the composite bonds to the living tissue in such a manner that a portion of the collagen part is digested and absorbed to be replaced by the invading connective tissue and a part of collagen near the surface of the synthetic polymers had escaped di...Continue Reading


Sep 1, 1977·Journal of Biomedical Materials Research·M Chvapil
Mar 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·I RuckerL D Zeleznick
Sep 1, 1972·The Journal of Cell Biology·T Elsdale, J Bard

Related Concepts

Process of Absorption
Hemocompatible Materials
Composite Resins
Connective Tissue
X-Rays, Nuclear

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