Studies on Cytotoxic Activity against HepG-2 Cells of Naphthoquinones from Green Walnut Husks of Juglans mandshurica Maxim

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yuanyuan ZhouHai-Xue Kuang

Abstract

Twenty-seven naphthoquinones and their derivatives, including four new naphthalenyl glucosides and twenty-three known compounds, were isolated from green walnut husks, which came from Juglans mandshurica Maxim. The structures of four new naphthalenyl glucosides were elucidated based on extensive spectroscopic analyses. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HepG-2 by MTT [3-(4,5-dimethylthiazo l-2-yl)-2,5 diphenyl tetrazolium bromide] assay. The results were shown that most naphthoquinones in an aglycone form exhibited better cytotoxicity in vitro than naphthalenyl glucosides with IC50 values in the range of 7.33-88.23 μM. Meanwhile, preliminary structure-activity relationships for these compounds were discussed.

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Citations

Jan 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoo Jin LeeEun Kyoung Seo
Apr 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li YangQiang Wang
Mar 18, 2017·Journal of Asian Natural Products Research·Jing LiGui-Shan Tan
Dec 30, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dan WangLisi Zhang
Dec 30, 2017·Natural Product Research·Jingjing LiangHanli Ruan
May 30, 2019·Natural Product Research·Yi LinHanli Ruan
Sep 22, 2020·Natural Product Research·Yuan-Yuan ZhouHai-Xue Kuang
Feb 18, 2017·Natural Product Research·Yuan-Yuan ZhouHaixue Kuang
May 5, 2018·Natural Product Research·Qin YangShu-Min Zhang
Feb 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Niraj ChaudharyHari Prasad Devkota
Nov 13, 2018·Natural Product Research·Yuan-Yuan ZhouHai-Xue Kuang
Mar 10, 2017·Journal of Asian Natural Products Research·Guo-Dong YaoShao-Jiang Song
Mar 28, 2019·Archives of Pharmacal Research·Jung Wha Kim, Sang Hee Shim
Aug 15, 2019·International Journal of Molecular Sciences·Ali Jahanban-EsfahlanRyszard Amarowicz
Nov 30, 2019·Phytochemistry·Xiaogang PengHanli Ruan
Feb 27, 2021·Chemistry & Biodiversity·Chenxi ZhuSandra Loesgen
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela Soto-MadridSilvia Matiacevich
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wolfgang Robien

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Methods Mentioned

BETA
NMR
column chromatography
Assay

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