PMID: 590200Oct 1, 1977

Studies on diabetic syndrome and influences of long-term tolbutamide administration in Mongolian gerbils (Meriones unguiculatus)

Endocrinologia Japonica
K Nakama

Abstract

Sixty-seven mongolian gerbils (Meriones unguiculatus), which seem to resemble the sand rats in the manifestation of diabetic syndrome, were used for observations on the development of diabetic process and on the effect of the long term administration of tolbutamide on it. The mean blood glucose (158.2 +/- 14.7 mg/100 ml), mean serum NEFA (0.70 +/- 0.34 mEq/l) and mean serum IRI (68.9 +/- 10.2 muU/ml) in mongolian gerbils were relatively higher than those in rats. Diabetes-like processes found in the pancreas of mongolian gerbils were roughly grouped into two main types: (1) the histopathological process in which the fibrosis, initially prominent at perivascular space, spread to the islets, finally producing the islet's cell degeneration, and (2) the process of diffuse islet's hyperplasia. These two processes were considered to differ from each other, the former being affected by tolbutamide and the latter remaining unaffected. After breeding on the diet containing 0.1 -0.2% tolbutamide for 6 months, there was a general inclination of an increase of cases of severe pathological findings, and the distribution probabilities of the cases carrying the severe fibrotic process in heart, that is, the process from endothelial cell swell...Continue Reading

Citations

Jan 1, 1978·General Pharmacology·A Y Chang
Jun 1, 1980·Experimental Aging Research·A L VincentW A Sodeman
Dec 27, 2018·Journal of Biological Rhythms·Carmel BiluNoga Kronfeld-Schor
Jan 1, 1986·Experimental Aging Research·M L Cheal

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Blood Glucose
Streptozotocin Diabetes
Nonesterified Fatty Acids
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Novolin
Myocardium
Pancreas
Tolbutamid R.A.N.

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