PMID: 9556Aug 1, 1976

Studies on drug-induced lipidosis: VII. Effects of bis-beta-diethyl-aminoethylether of hexestrol, chloroquine, homochlorocyclizine, prenylamine, and diazacholesterol on the lipid composition of rat liver and kidney

Lipids
A YamamotoK Seki

Abstract

4,4'-Bis (beta-diethylaminoethoxy)-alpha, beta-diethyldiphenylethane (DH), which had been shown to induce a type of lipidosis resembling Niemann-Pick disease, was given to rats at a dose of 20, 50, 100, and 150 mg/kg body weight per day for 1 or 2 weeks. An enlargement of the liver with marked increases in free cholesterol, total phospholipids, and phosphatidylinositol took place by administration of a larger dose. The increase in bis (monoacylglyceryl) phosphate (BMGP), which is peculiar to this kind of drug-induced lipidosis, was dependent upon the dose of the drug as well as the length of time. Similar changes were also observed in kidney. Among several other drugs tested, chloroquine and diazacholesterol brought on as much increase in BMGP as treatment with DH.

References

Mar 1, 1971·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·S AdachiT Kitani
Oct 28, 1969·Biochimica Et Biophysica Acta·B J Burns, J C Elwood
Feb 1, 1971·Hoppe-Seyler's Zeitschrift für physiologische Chemie·P N SengH R Wiedemann
Oct 1, 1963·Archives of Biochemistry and Biophysics·T E MORGAND J HANAHAN

Citations

Jan 1, 1981·European Journal of Clinical Pharmacology·A LageronM Gautier
Nov 29, 1983·Biochimica Et Biophysica Acta·N SternM Wolman
Jan 23, 1989·Biochimica Et Biophysica Acta·S Huterer, J R Wherrett
Feb 15, 1985·Biochemical Pharmacology·A PappuK Y Hostetler
Jan 1, 1981·Journal of Toxicology and Environmental Health·T BenjaminE K Weisburger
Apr 1, 1982·Antimicrobial Agents and Chemotherapy·R Chevli, C D Fitch
Apr 1, 1984·Environmental Health Perspectives·Z Hruban
Apr 8, 2010·Expert Opinion on Drug Metabolism & Toxicology·Elizabeth A TengstrandFrank Y Hsieh
Jan 2, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Yoshiji AsaokaYohei Miyamoto
Oct 28, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F Hullin-MatsudaI Delton-Vandenbroucke
Apr 28, 2009·Toxicology and Applied Pharmacology·Rebecca A ClewellMelvin E Andersen
Jun 25, 2009·ChemMedChem·Juha-Matti AlakoskelaPaavo K J Kinnunen
Feb 15, 1986·Archives of Biochemistry and Biophysics·G L ChenW W Chen
May 1, 1984·Biochemical Pharmacology·A HallbergA Andersson
Jan 1, 1978·Biochemical Pharmacology·T YanagitaN Enomoto
Sep 15, 1990·Biochemical Pharmacology·P S TietzN F LaRusso
Jan 1, 1978·Biochemical Pharmacology·H LüllmannO Wassermann
Dec 1, 1979·Biochemical Pharmacology·H Lüllmann, M Wehling
Sep 16, 1998·Antimicrobial Agents and Chemotherapy·J E RuscoeB K Park

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