PMID: 2378Jan 1, 1976

Studies on fazadinium bromide (ah 8165): a new non-depolarizing neuromuscular blocking agent

Canadian Anaesthetists' Society Journal
R HughesN Sugai

Abstract

Intravenous dose-response relationships were used to correlate neuromuscular paralysis with the effects of fazadinium (AH 8165) on autonomic mechanisms in anaesthetized cats and rhesus monkeys and with cardiovascular effects in man. In cats and monkeys neuromuscular paralysis of the twitch responses of the gastrocnemius muscle by fazadinium was accompanied by impairment of the vagally induced bradycardia, but cardiovascular disturbances were small. Blockade of sympathetic mechanisms and hypotension were only evident with supra-maximal doses. In man tachycardia was a common occurrence and in some patients hypertension occurred with doses of the drug needed for complete neuromuscular paralysis. Fazadinium was three to four times more potent in rhesus monkeys than in cats and its course of action was considerably longer. The potency of the drug in man corresponded more closely to that in cats than in rhesus monkeys but its course of action in patients was similar to that in monkeys. In man, dose-response curves were constructed for the contractions of the adductor pollicis muscles elicited by tetanic and single twitch stimuli applied to the corresponding ulnar nerves. The onset of paralysis of the tetanic contractions after the in...Continue Reading

References

Aug 1, 1973·British Journal of Anaesthesia·R T Brittain, M B Tyers

Citations

Mar 7, 2002·British Journal of Anaesthesia·C Lee
Aug 1, 1979·Acta Anaesthesiologica Scandinavica·S Z HussainA T Birmingham
Aug 1, 1984·Journal of Pharmacological Methods·R Hughes
Apr 23, 2009·Current Opinion in Anaesthesiology·Mohamed Naguib, Sorin J Brull

Related Concepts

Metazoa
Anthropoidea
Diastolic Blood Pressure
Felis catus
Neuromuscular Nondepolarizing Agents
Dose-Response Relationship, Drug
Pulse Rate
Intravenous Injections
Macaca mulatta
Inotropism

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