PMID: 2502456May 1, 1989Paper

Studies on follicular atresia: role of gonadotropins and gonadal steroids in regulating cathepsin-D activity of preovulatory follicles in the rat

Molecular and Cellular Endocrinology
N Dhanasekaran, N R Moudgal

Abstract

Preovulatory follicular atresia was studied using pregnant mare serum gonadotropin (PMSG)-primed rats (15 IU/rat) which were deprived of hormonal support either by allowing the metabolic clearance of the PMSG or by injecting a specific PMSG antiserum (PMSG a/s). Atresia was monitored by an increase in lysosomal cathepsin-D activity and a decrease in the receptor activity of the granulosa cells (GC) isolated from the preovulatory follicles. It was shown that the increase in lysosomal activity and the decrease in receptor activity seen at 96 h after PMSG (or PMSG plus PMSG a/s) could be arrested both by follicle stimulating hormone (FSH) and luteinizing hormone (LH). Injection of cyanoketone or clomiphene citrate together with FSH/LH prevented this 'rescue' suggesting a role for estrogens in the regulation of atresia. Although the administration of estradiol-17 beta (20 micrograms/rat) together with PMSG a/s could show a 'rescue effect' in terms of reduction in cathepsin-D activity the gonadotropin receptor activities of these granulosa cells were not restored. The injection of dihydrotestosterone (DHT) to 48 h PMSG-primed rats induced atresia as noted by an increase in cathepsin-D activity. However, the exogenous administration ...Continue Reading

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Citations

Aug 26, 2003·Theriogenology·Israel Alonso-PozosAdolfo Rosado-García
Feb 13, 2010·Fertility and Sterility·Jong Yeob ChoiDoo Seok Choi
May 20, 2003·Reproduction in Domestic Animals = Zuchthygiene·A T Peter, N Dhanasekaran
Mar 11, 2003·Endocrine Journal·Yoshiaki YamagataHiroshi Kato
May 10, 2015·Molecular and Cellular Endocrinology·Katsumi TodaToshiji Saibara
Oct 30, 2004·The Journal of Reproduction and Development·Noboru ManabeTakashi Miyano
Nov 26, 1999·Journal of Cellular Biochemistry·G GebauerN Dhanasekaran
May 20, 2000·Annals of the New York Academy of Sciences·A Chryssikopoulos

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