Studies on functional roles of the histaminergic neuron system by using pharmacological agents, knockout mice and positron emission tomography

The Tohoku Journal of Experimental Medicine
T Watanabe, K Yanai

Abstract

Since one of us, Takehiko Watanabe (TW), elucidated the location and distribution of the histaminergic neuron system in the brain with antibody raised against L-histidine decarboxylase (a histamine-forming enzyme, HDC) as a marker in 1984 and came to Tohoku University School of Medicine in Sendai, we have been collaborating on the functions of this neuron system by using pharmacological agents, knockout mice of the histamine-related genes, and, in some cases, positron emission tomography (PET). Many of our graduate students and colleagues have been actively involved in histamine research since 1985. Our extensive studies have clarified some of the functions of histamine neurons using methods from molecular techniques to non-invasive human PET imaging. Histamine neurons are involved in many brain functions, such as spontaneous locomotion, arousal in wake-sleep cycle, appetite control, seizures, learning and memory, aggressive behavior and emotion. Particularly, the histaminergic neuron system is one of the most important neuron systems to maintain and stimulate wakefulness. Histamine also functions as a bioprotection system against various noxious and unfavorable stimuli (for examples, convulsion, nociception, drug sensitization...Continue Reading

Citations

Dec 7, 2002·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Takehiko Watanabe, Hiroshi Ohtsu
Mar 12, 2004·Nuclear Medicine and Biology·Hideki MochizukiKiichi Ishiwata
Dec 14, 2002·Pharmacology, Biochemistry, and Behavior·Shinobu SakuradaTsukasa Sakurada
Oct 22, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kazuhiko YanaiShinobu Sakurada
Jun 7, 2014·Pharmacological Reports : PR·Mariusz J Świąder, Stanisław J Czuczwar
Apr 28, 2011·Expert Opinion on Drug Safety·Kazuhiko YanaiNobuyuki Okamura
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Apr 19, 2008·Journal of Neurochemistry·Anayansi Molina-Hernández, Iván Velasco
Mar 22, 2012·Journal of Food Science·Y F LiH Kurihara
Feb 8, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kentaro IwabuchiKazuhiko Yanai
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Jul 17, 2004·The European Journal of Neuroscience·Michiko KanoKazuhiko Yanai
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Aug 4, 2020·British Journal of Pharmacology·Takeo YoshikawaKazuhiko Yanai
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Dec 1, 2020·Frontiers in Pharmacology·Takafumi HayashiShinobu Sakurada
May 2, 2017·Pharmacology & Therapeutics·Kazuhiko YanaiManabu Tashiro

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