PMID: 1208599Dec 11, 1975Paper

Studies on gluconeogenesis and ketogenesis in isolated hepatocytes from alloxan diabetic rats

Proceedings of the Society for Experimental Biology and Medicine
S R Wagle, W R Ingebretsen

Abstract

Gluconeogenesis and ketogenesis were studied in isolated hepatocytes obtained from normal and alloxan diabetic rats. Insulin treatment maintained near-normal blood glucose levels and caused an increase in glycogen deposition. The third day after insulin withdrawal the rats displayed a diabetic syndrome marked by progressive hyperglycemia and glycogen depletion. Net glucose production in liver cells isolated from alloxan diabetic rats progressively increased with time up to 72 hr after the last in vivo insulin injection. Maximal glucose production was observed at 72 hr with 10 mM alanine, lactate, pyruvate, or fructose. Glucose production decreased at 96 hr. The same pattern was observed with the incorporation of labeled bicarbonate into glucose. Ketogenesis in liver cells and hepatic lipid content also peaked at 72 hr.

Citations

May 1, 1987·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·S A Suleiman, J B Stevens
Jan 1, 1995·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·C MassonJ L Guéant
Feb 18, 1998·Medical Hypotheses·V V VinogradovS V Vinogradov

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