Studies on gonococcus infection. XVII. IgA1-cleaving protease in vaginal washings from women with gonorrhea

The Journal of Infectious Diseases
M BlakeJ Swanson

Abstract

Vaginal washings from women attending a veneral disease clinic were examined for the presence of protease that cleaved IgA subclass 1 (IgA1). In a crude assay, vaginal washings cleaved [125I]IgA1 in 19 of 25 specimens from individuals from whom Neisseria gonorrhoeae were cultivated. Forty-six specimens from 104 women whose cultures were negative for N. gonorrhoeae also cleaved [125I]IgA1. Vaginal washings from six of six women with culture-proven gonorrhea cleaved [125I]IgA1 into low-molecular-weight components identical to those produced by partially purified IgA1-specific protease from gonococci. The hydrolysis of [125I]IgA1 by vaginal washings from women whose cultures were negative for N. gonorrhoeae yielded cleavage products that resembled those of trypsin or alpha-chymotrypsin. These findings indicate that gonococci residing in the female genital tract produce IgA1-specific protease that can be detected in the vaginal washings of infected women.

Citations

May 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M KilianE V Frandsen
May 23, 2012·Advances in Bioscience and Biotechnology·Bernard J MonclaPhillip W Graebing
Sep 11, 2013·Vaccine·Ann E JerseMichael W Russell
Jun 1, 1989·European Journal of Epidemiology·T TsujiT Miwatani
May 1, 1992·Journal of Periodontal Research·R L GregoryD R Lloyd
Feb 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·C H Sørensen, M Kilian
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bernard W Senior, Jenny M Woof
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bernard W Senior, Jenny M Woof

Related Concepts

SDS-PAGE
Gonorrhea
IgG2B
Neisseria gonorrhoeae
Peptide Hydrolases
Vagina

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