PMID: 67153Feb 1, 1977Paper

Studies on H-2 specificities on mouse tumour cells by a new microradioassay

Journal of Immunogenetics
F GarridoH Festenstein

Abstract

Seven mouse tumour cell lines of different aetiology and origin were tested for the expression of surface alloantigens using twenty-four well defined H-2 alloantisera and anti-Thy 1.2. We used a new radioassay that involves antibody-complement treatment of the tumour target cells followed by postlabeling the surviving tumour cells with 14C-thymidine. With a relatively high frequency the anti-H-2 sera were reacting differently with the tumour cells than with respective syngeneic lymphoid cells. Thirty-six anomalous reactions out of 129 investigated were detected. Absorbtion experiments performed with H-2 antigen positive or negative lymphoid cells revealed a striking similarity between these extra-specificities and H-2 specificities of foreign haplotypes. The results are discussed in relation to the biological importance of the extra-specificities, both with regard to origin (derepression) and function (transplantation antigen properties).

References

Nov 15, 1975·International Journal of Cancer. Journal International Du Cancer·G Parmiani, G Invernizzi
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Apr 1, 1975·European Journal of Immunology·U Koszinowski, R Thomssen
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Jul 16, 2010·International Journal of Telemedicine and Applications·George J MandellosDimitrios K Lymberopoulos

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Citations

Dec 1, 1978·Immunogenetics·R M MaizelsL Hood
Jan 1, 1997·International Journal of Clinical & Laboratory Research·I AlgarraF Garrido
Sep 1, 1982·European Journal of Cancer & Clinical Oncology·E KedarE Klein
Apr 1, 1977·Journal of Immunogenetics·F GarridoH Festenstein
Jan 1, 1981·Immunological Reviews·H Festenstein, W Schmidt
Apr 1, 1982·Journal of Immunogenetics·S MayerJ P Bergerat
Apr 1, 1979·Journal of Immunogenetics·F GarridoM D Torres
Jan 1, 1979·Immunological Communications·F Merino
Feb 1, 1980·Journal of Immunogenetics·V SchirrmacherM D Torres

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