Studies on hepatoprotective, antispasmodic and calcium antagonist activities of the aqueous-methanol extract of Achillea millefolium

Phytotherapy Research : PTR
Sheikh YaeeshAnwarul Hassan Gilani

Abstract

The crude extract of Achillea millefolium (Am.Cr) was studied for its possible hepatoprotective effect against d-galactosamine (d-GalN) and lipopolysaccharide (LPS) induced hepatitis in mice and antispasmodic effect in isolated gut preparations to rationalize some of the folklore uses. Co-administration of d-GalN (700 mg/kg) and LPS (25 microg/kg) produced 100% mortality in mice. Pre-treatment of animals with Am.Cr (300 mg/kg) reduced the mortality to 40%. Co-administration of d-GalN (700 mg/kg) and LPS (1 microg/kg) significantly raised the plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels compared with values in the control group (p < 0.05). Pre-treatment of mice with Am.Cr (150-600 mg/kg) significantly prevented the toxins induced rise in plasma ALT and AST (p < 0.05). The hepatoprotective effect of Am.Cr was further verified by histopathology of the liver, which showed improved architecture, absence of parenchymal congestion, decreased cellular swelling and apoptotic cells, compared with the toxin group of animals. In isolated rabbit jejunum preparations, Am.Cr caused a concentration-dependent (0.3-10 mg/mL) relaxation of both spontaneous and K(+)-induced contractions as well as shifting the ...Continue Reading

References

Jan 1, 1977·Annual Review of Pharmacology and Toxicology·A Fleckenstein
Nov 9, 1979·Science·F A SchanneJ L Farber
Jan 1, 1991·General Pharmacology·A J FarreB Gutierrez
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I HishinumaI Yamatsu
Mar 1, 2002·Pharmacological Reviews·Adam Szewczyk, Lech Wojtczak
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL

❮ Previous
Next ❯

Citations

Oct 1, 2011·Asian Pacific Journal of Tropical Biomedicine·Sundaram Ravikumar, Murugesan Gnanadesigan
Apr 25, 2014·Advanced Biomedical Research·Saeed NiazmandElahe Fereidouni
Jan 25, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Elisângela DüsmanVeronica Elisa Pimenta Vicentini
Jan 24, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Rainer W Bussmann
Oct 6, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Osman Tuncay AgarFatma Pinar Turkmenoglu
Aug 18, 2010·Journal of Ethnopharmacology·Ugur Cakilcioglu, Ismail Turkoglu
Nov 11, 2008·Journal of Ethnopharmacology·Sara VitaliniGelsomina Fico
Aug 21, 2013·The Journal of Membrane Biology·Muhammad Akram
Jun 28, 2011·Journal of Ethnopharmacology·Ugur CakilciogluSukru Hayta
Jun 14, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Mansour S Al-SaidHusnu C Baser
Feb 10, 2017·Journal of Ethnopharmacology·Majid MohammadhosseiniAbolfazl Akbarzadeh
Jan 20, 2017·BMC Complementary and Alternative Medicine·Arif-Ullah KhanMuhammad Iqbal Choudhary
Dec 18, 2015·Dose-response : a Publication of International Hormesis Society·Somayeh ShahaniSeyed Jalal Hosseinimehr
Sep 22, 2010·Phytotherapy Research : PTR·Arif-ullah Khan, Anwarul Hasan Gilani
Sep 27, 2014·Phytotherapy Research : PTR·Gulzar MuhammadAnwarul-Hassan Gilani
Nov 8, 2006·Phytotherapy Research : PTR·Farooq AnwarAnwarul Hassan Gilani
Apr 4, 2019·Journal of Medicinal Food·Mitzzy F Medellín-LunaAlberto R Cervantes-Villagrana
Dec 14, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F BorrelliA A Izzo
Jul 1, 2017·World Journal of Hepatology·Yasemin H BalabanUfuk Koca-Caliskan
Jul 20, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Farshad Hassanzadeh-Kiabi, Babak Negahdari
Jun 16, 2017·Phytotherapy Research : PTR·Sofi Imtiyaz AliV Venkatesalu
Apr 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jeong Yoon KimKi Hun Park
Oct 13, 2017·Pakistan Journal of Biological Sciences : PJBS·Yahya Saleh Al-AwthanWaleed Ahmed Alril

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.