PMID: 8599065Jul 1, 1995Paper

Studies on human anti-rabies immunization in Brazil. I--Evaluation of the 3 + 1 pre-exposure vaccination schedule under field conditions

Revista Do Instituto De Medicina Tropical De São Paulo
C R ZanettiO A Pereira

Abstract

The currently used pre-exposure anti-rabies immunization schedule in Brazil is the one called 3+1, employing suckling mouse brain vaccine (3 doses on alternate days and the last one on day 30). Although satisfactory results were obtained in well controlled experimental groups using this immunization schedule, in our routine practice, VNA levels lower than 0.5 IU/ml are frequently found. We studied the pre-exposure 3+1 schedule under field conditions in different cities on the State of São Paulo, Brazil, under variable and sometimes adverse circumstances, such as the use of different batches of vaccine with different titers, delivered, stored and administered under local conditions. Fifty out of 256 serum samples (19.5%) showed VNA titers lower than 0.5 IU/ml, but they were not distributed homogeneously among the localities studied. While in some cities the results were completely satisfactory, in others almost 40% did not attain the minimum VNA titer required. The results presented here, considered separately, question our currently used procedures for human pre-exposure anti-rabies immunization. The reasons determining this situation are discussed.

References

Jan 14, 1988·The New England Journal of Medicine·D B FishbeinE H Weir
May 1, 1993·Revista Do Instituto De Medicina Tropical De São Paulo·S R FavorettoO A Pereira
Mar 1, 1993·Revista Do Instituto De Medicina Tropical De São Paulo·S R FavorettoO A Pereira

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Citations

Jan 7, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C R ZanettiO A Pereira
Oct 1, 2006·Journal of Applied Oral Science : Revista FOB·Nemre Adas SalibaAna Valéria Pagliari Tiano
Dec 1, 1996·Promotion & Education·M F WestphalM G Maciel

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