PMID: 8599066Jul 1, 1995Paper

Studies on human anti-rabies immunization in Brazil. II--Preliminary evaluation of the 2-1-1 schedule for human pre-exposure anti-rabies immunization, employing suckling mouse brain vaccine

Revista Do Instituto De Medicina Tropical De São Paulo
C R ZanettiO A Pereira

Abstract

This study reports preliminary results of virus neutralizing antibody (VNA) titers obtained on different days in the course of human anti-rabies immunization with the 2-1-1 schedule (one dose is given in the right arm and one dose in the left arm at day 0, and one dose is applied on days 7 and 21), recommended by WHO for post-exposure treatment with cell culture vaccines. A variant schedule (double dose on day zero and another on day 14) was also tested, both employing suckling mouse brain vaccine. A complete seroconversion rate was obtained after only 3 vaccine doses, and almost all patients (11 of 12) presented titers higher than 1.0 IU/ml. Both neutralizing response and seroconversion rates were lower in the group receiving only 3 doses, regardless of the sample collecting day. Although our results are lower than those found with cell culture vaccines, the geometry mean of VNA is fully satisfactory, overcoming the lower limit recommended by WHO of 0.5 IU/ml. The 2-1-1 schedule could be an alternative one for pre exposure immunization, shorter than the classical 3+1 regimen (one dose on days 0, 2, 4 and 30) with only three visits to the doctor, instead of four.

References

Aug 1, 1991·Clinical and Experimental Immunology·M HerzogM Lafon
May 1, 1993·Revista Do Instituto De Medicina Tropical De São Paulo·S R FavorettoO A Pereira
Mar 1, 1993·Revista Do Instituto De Medicina Tropical De São Paulo·S R FavorettoO A Pereira
Jul 1, 1995·Revista Do Instituto De Medicina Tropical De São Paulo·C R ZanettiO A Pereira

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Citations

Nov 14, 2014·Clinical and Vaccine Immunology : CVI·Jiangping RenZhenyu Gong
Jan 7, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C R ZanettiO A Pereira

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