Studies on human epidermal Langerhans cells III. Induction of T lymphocyte response to nickel sulphate in sensitized individuals

The British Journal of Dermatology
L R Braathen

Abstract

Human epidermis from nickel sensitive patients was separated from dermis by means of a suction blister device and dissociated with trypsin. The epidermal cell suspensions obtained contained 3--5% Langerhans cells as judged by immunofluorescence staining of the cells with a rabbit anti-DR antiserum. The epidermal cells were co-cultured with purified autologous T lymphocytes with or without nickel sulphate. A strong proliferative T lymphocyte response to nickel sulphate was obtained provided epidermal cells were also present. Pretreatment of the epidermal cells with anti-DR antiserum abolished or greatly reduced the response. These data indicate that epidermal cells are able to present nickel sulphate to T lymphocytes in an immunogenic way. Since the responsible cells were DR antigen positive, it is highly probable that the cells responsible for these functions are the Langerhans cells.

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Citations

Mar 1, 1991·International Journal of Dermatology·O Baadsgaard, T Wang
Feb 1, 1987·Immunology and Cell Biology·G M Halliday, H K Muller
May 1, 1985·Scandinavian Journal of Immunology·J Austad, L R Braathen
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Sep 1, 1990·Scandinavian Journal of Immunology·O BaadsgaardG Lange-Vejlsgaard
Dec 1, 1981·The British Journal of Dermatology·J Austad, N J Mørk
Sep 1, 1983·The British Journal of Dermatology·L R Braathen, T Kaaman
Jul 1, 1985·Cell and Tissue Kinetics·G M Morris, J W Hopewell
Oct 30, 2001·Acta Odontologica Scandinavica·M Streit, L R Braathen
Nov 1, 1986·Immunological Investigations·C A PicutR M Lewis
Oct 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·B SpörriL R Braathen
Apr 1, 1988·The British Journal of Dermatology·J AshworthS M Breathnach
Feb 1, 1993·The British Journal of Dermatology·C U BrandL R Braathen

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