PMID: 2100752Jan 1, 1990Paper

Studies on immunomodulatory properties of isoniazid. IV. Effect of isoniazid on T lymphocyte activation by phorbol ester tumor promoter

Journal of hygiene, epidemiology, microbiology, and immunology
E J Kucharz, S J Sierakowski

Abstract

Human peripheral blood T cells or continuous T cell lines were treated with phorbol myristate (PMA), a direct protein kinase C activator. The effect of isoniazid on PMA-treated cells was investigated. It was found that low doses of isoniazid augmented proliferation of T cells treated with PMA or stimulated with PMA and phytohemagglutinin. Similar results were shown in the Jurkat cell line. There was no influence of isoniazid upon proliferation of PMA-treated HT-2 cells, interleukin 2-dependent cell line. The obtained results suggest that, at least one target mechanism of isoniazid is located in T cell activation pathway after protein kinase C activation.

Related Concepts

Related Feeds

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Related Papers

Biochemical and Biophysical Research Communications
N MukaidaT Kasahara
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Faribourz PayvandiDavid I Stirling
The Journal of Immunology : Official Journal of the American Association of Immunologists
J VilcekJ Le
© 2021 Meta ULC. All rights reserved