Studies on internal structure of tablets. VI. stress dispersion in tablets by excipients

Chemical & Pharmaceutical Bulletin
H YuasaY Kanaya

Abstract

The aim of this study was to reduce the stress concentration of a medicine by dispersing the stress in tablets at tableting by addition of excipients. The mechanism of the stress dispersion was elucidated. Phenacetin (PHE) was used as a model of crystalline medicine with a high brittleness, and the degree of stress dispersion was evaluated by the change in the exposed surface area of PHE. To learn the mechanical strength of tablets, the crushing strength and friability were measured, their internal structure was analyzed by the porosity and pore size distribution, and stress relaxation experiments were performed. The results were as follows. Calcium silicate (Florite RE, FLR) showed a high stress dispersion effect, adding a high formability and mechanical strength to tablets. It was thought that the high stress dispersion resulted from the rapid stress relaxation caused by the plastic deformation and brittleness fracture of pores in FLR under a low compression pressure. Thus the stress caused locally on PHE particles may disperse.

Citations

Jan 18, 2006·AAPS PharmSciTech·Sameer SharmaAtmaram P Pawar
Mar 23, 2011·Drug Development and Industrial Pharmacy·Yukoh Sakata, Hiroyuki Yamaguchi
May 2, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yue TengHong Wen
Jun 8, 2007·Pharmaceutical Research·Kazuyuki ShimizuYukiharu Nakayama
Nov 30, 2006·The Journal of Pharmacy and Pharmacology·Nobuaki HiraiKoichi Takahashi
Dec 17, 2002·Journal of Traumatic Stress·Noreen Tehrani

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