Studies on liposome-encapsulated heparin

Thrombosis Research
T D KimT Mori

Abstract

In order to prolong the anticoagulant activity of heparin in vivo, attempts were made to encapsulate heparin into liposomes. Liposome-encapsulated heparin (lipo-heparin) prepared was large multilamellar vesicles (0.5-4.0 micron in diameter). The activity of lipo-heparin was 1.6-5.2 X 10(3) U/g lipid with recovery rate ranged between 0.4 to 1.3% and stable in saline at 4 degrees C for at least two weeks. When intravenously administered into rats, the anticoagulant activity of lipo-heparin was significantly prolonged (approximately three times), as compared with that of untreated heparin. Furthermore, the activity of lipo-heparin could be neutralized by protamine sulfate. From these observations, it was concluded that liposome-encapsulation of heparin results in the prolonged anticoagulant effect in vivo and lipo-heparin may be applicable for clinical use, after further studies on side effects of liposomes are completed.

References

Sep 17, 1977·Lancet·E Marciniak, J P Gockerman
Feb 1, 1976·FEBS Letters·H M Patel, B E Ryman
Dec 28, 1979·Biochemical and Biophysical Research Communications·E A Forssen, Z A Tökes
Mar 1, 1978·European Journal of Immunology·B RivnayM Shinitzky
Dec 14, 1976·Biochimica Et Biophysica Acta·D A TyrrellB E Ryman
May 1, 1968·European Journal of Biochemistry·K R BruckdorferC Green
Jun 1, 1982·Chemical & Pharmaceutical Bulletin·M UenoN Sakuragawa

❮ Previous
Next ❯

Citations

Jan 16, 2004·Archives of Pharmacal Research·So Yean ChoYeong Shik Kim
Nov 1, 1989·Thrombosis Research·T D KimT Mori
Apr 17, 2015·Journal of Advanced Pharmaceutical Technology & Research·Satheesh JogalaJithan Aukunuru
Jan 1, 1990·Biomaterials, Artificial Cells, and Artificial Organs·T Chandy, C P Sharma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.