Studies on mechanism of retching and vomiting in dogs. Effect of peripheral dopamine blocker on myoelectric changes in antrum and upper small intestine

Digestive Diseases and Sciences
K Y LeeW Y Chey

Abstract

In five conscious dogs prepared with a gastric cannula and platinum monopolar electrodes in the antrum, duodenum, and jejunum, the effect of dopamine or copper sulfate on the myoelectric activity was studied. During phase I of interdigestive myoelectric activity, retching, and/or vomiting occurred in 1.6 +/- 0.2 (mean +/- SE) min after intravenous bolus injection of dopamine (50 micrograms/kg) or in 8.7 +/- 1.8 min after intragastric administration of copper sulfate (2%, 50 mg). Immediately prior to the retching and/or vomiting act, a group of disordered myoelectric activities occurred, including retrograde-moving trains of spike activity starting from the jejunum and the subsequent tachyarrhythmia in the antrum. These motility changes also occurred in the two anesthetized dogs so studied. Both the retching and/or vomiting act and the abnormal myoelectric activity which were induced by dopamine and by copper sulfate were prevented by intravenous administration of a peripheral dopamine blocker, domperidone, 5 mg, in 100% and 70%, respectively. Although domperidone could not prevent the retching and/or vomiting induced by copper sulfate in three of 10 experiments, it delayed the onset of vomiting from 8.7 +/- 1.8 to 14.5 +/- 5.3 ...Continue Reading

References

Jun 11, 1979·Life Sciences·C J Niemegeers, P A Janssen
Sep 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·M BaudryJ C Schwartz
Apr 1, 1972·Journal of Applied Physiology·P Bass, J N Wiley
Feb 1, 1951·The American Journal of Physiology·S C WANG, H L BORISON
Jul 15, 1946·The Journal of Physiology·R A Gregory

❮ Previous
Next ❯

Citations

Mar 1, 1988·Digestive Diseases and Sciences·R D CheyW Y Chey
Apr 1, 1989·Digestive Diseases and Sciences·Y H JoM S Kim
Mar 1, 1990·Digestive Diseases and Sciences·C DefilippiF Cumsille
Jan 1, 1988·Baillière's Clinical Gastroenterology·P L Andrews, J Hawthorn
Aug 15, 2014·Clinical and Experimental Pharmacology & Physiology·Gregory O'GradyLeo K Cheng
Oct 2, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Makoto TatewakiToku Takahashi
Aug 12, 2005·European Journal of Gastroenterology & Hepatology·David WicksRobin Spiller
Nov 18, 2014·World Journal of Gastroenterology : WJG·Hiroyuki AndoHiroyuki Kuwano
Jan 23, 2020·Digestive Diseases and Sciences·Hiroyuki KuwanoKen Shirabe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.