Studies on medicinal herbs for cognitive enhancement based on the text mining of Dongeuibogam and preliminary evaluation of its effects

Journal of Ethnopharmacology
Malk Eun PakByung Tae Choi

Abstract

In literature on Korean medicine, Dongeuibogam (Treasured Mirror of Eastern Medicine), published in 1613, represents the overall results of the traditional medicines of North-East Asia based on prior medicinal literature of this region. We utilized this medicinal literature by text mining to establish a list of candidate herbs for cognitive enhancement in the elderly and then performed an evaluation of their effects. Text mining was performed for selection of candidate herbs. Cell viability was determined in HT22 hippocampal cells and immunohistochemistry and behavioral analysis was performed in a kainic acid (KA) mice model in order to observe alterations of hippocampal cells and cognition. Twenty four herbs for cognitive enhancement in the elderly were selected by text mining of Dongeuibogam. In HT22 cells, pretreatment with 3 candidate herbs resulted in significantly reduced glutamate-induced cell death. Panax ginseng was the most neuroprotective herb against glutamate-induced cell death. In the hippocampus of a KA mice model, pretreatment with 11 candidate herbs resulted in suppression of caspase-3 expression. Treatment with 7 candidate herbs resulted in significantly enhanced expression levels of phosphorylated cAMP respon...Continue Reading

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Citations

Apr 30, 2017·Scientia pharmaceutica·Kandhasamy Sowndhararajan, Songmun Kim
Mar 28, 2018·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·So Hyun ParkByung Tae Choi
Apr 20, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Yu Ri KimByung Tae Choi
Oct 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaohui JiaHaimin Lei
Jan 23, 2021·Pharmaceutics·Maria D AuxteroAna I Fernandes
Sep 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kandhasamy SowndhararajanSongmun Kim

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