PMID: 12389Aug 1, 1976Paper

Studies on monoamine oxidase. XVIII. Enzymic properties of placental monoamine oxidase

Japanese Journal of Pharmacology
T Egashira

Abstract

Enzymic properties of partially purified monoamine oxidase (MAO) from human placenta were studied with tyramine, serotonin and benzylamine as substrates. The highest activity was obtained with serotonin and almost no activity was observed with benzylamine. These results are similar to those obtained with rat placental MAO, but different from those with rabbit placental MAO. The Km values for serotonin and tyramine were found to be 0.21 mM and 0.23 mM, respectively and the pH optimum was 8.1 with either substrate. The thermal inactivation curves of this enzyme with the two substrates were identical. The pI curves for inhibition of MAO activity by harmine, pargyline and iproniazid were similar and almost the same pI 50 values for the respective inhibitors were obtained with the two substrates. MAO in human placenta differs from that in other organs, such as liver, brain and plasma from the standpoint of the substrate specificity and the inhibitor sensitivity. The possibility that human placenta contains a single form of MAO is discussed on the basis of the present results.

Citations

Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A W BachJ C Shih
Jan 1, 1987·Journal of Neural Transmission·C KonradiT Nagatsu
Jan 1, 1982·Journal of Neural Transmission·V GloverM Sandler
Apr 23, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·R Lewinsohn, M Sandler
Jan 1, 1992·Psychopharmacology·S W KwanC W Abell
Jan 1, 1994·Drug Metabolism Reviews·M S Benedetti, P Dostert
Oct 15, 1990·Biochemical Pharmacology·T ObataY Yamanaka
Apr 11, 2003·Journal of Pharmacological Sciences·Toru EgashiraKumiko Sakai
Sep 12, 2009·Neurotoxicology and Teratology·Nadia AbdelouahabLarissa Takser
Dec 31, 2003·Neurotoxicology·E Ellen Billett
Sep 29, 1998·Clinical and Experimental Pharmacology & Physiology·N M GudeS P Brennecke
May 30, 1997·The Journal of Biological Chemistry·Y Tsugeno, A Ito
Mar 22, 2001·Molecular Pharmacology·W K WongJ C Shih

Related Concepts

Brain
Bos indicus
Hydrogen-Ion Concentration
Mitochondria
Mitochondria, Liver
Monoamine Oxidase
RIMA (Reversible Inhibitor of Monoamine Oxidase A)
Placenta

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