PMID: 591465Nov 1, 1977

Studies on mycobacillin derivatives. IV. O-methylation of the antibiotic and identification of the active tyrosine residue

The Journal of Antibiotics
P C Banerjee


Methylation of myocobacillin with dimethyl sulfate and methyl iodide produced respectively mono- and di-methyl derivatives. the products were inactive against fungal spores and erythrocytes. Tyrosine hydroxyl groups only were methylated; in the monomethyl derivative, the hydroxyl of the tyrosine residue in position 6 is methylated, whereas the hydroxyl of the tyrosine in position 4 remains free; both hydroxyl groups are methylated in the dimethyl derivative. The results indicate that the hydroxyl group of the tyrosine residue in position 6 is essential for the biological activity of mycobacillin.


Jun 22, 2010·Chemistry & Biodiversity·Sergio Martínez-RodríguezFrancisco Javier Las Heras-Vázquez

Related Concepts

Antibiotics, Antifungal
Structure-Activity Relationship

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