Studies on N-nitroso bile acid amides in relation to their possible role in gastrointestinal cancer

Lipids
B Dayal, N H Ertel

Abstract

Cancers of the gastrointestinal tract account for a large proportion of neoplastic diseases which afflict humans. The etiology of gastrointestinal cancer has been attributed in part to exogenous carcinogens, such as food substances and environmental pollutants. Recent hypotheses suggest that carcinogens may arise endogenously. Evidence suggests that some bile acids and their isomeric metabolites may be involved in the pathogenesis of colon cancer. However, the mechanisms responsible for their cancer-promoting effect is not clear. We and others propose that one mechanism for the mitogenic effects of bile acids may be N-nitrosation of their glycine and taurine amides; human gastric aspirates do contain small quantities of N-nitroso compounds of other substrates. Many foods contain nitrites and nitrates, which can react with bile acid amides to form N-nitroso derivatives. Our recent studies demonstrated the potential for N-nitroso conjugate formation from ursodeoxycholic acid, a 7 beta-epimer of chenodeoxycholic acid used as a drug Actigall to dissolve gallstones. The N-nitroso derivative of this compound, a direct-acting carcinogen, has a long half-life and, once nitrosated is stable enough to survive passage through the gastroin...Continue Reading

References

Jul 12, 1975·Lancet·P CorreaM Archer
Mar 1, 1975·Toxicology and Applied Pharmacology·S S Mirvish
Mar 1, 1977·Clinics in Endocrinology and Metabolism·P M Daniel, C S Treip
May 1, 1978·The Biochemical Journal·G A HaslewoodD Wong
Aug 1, 1991·Chemistry and Physics of Lipids·B DayalV Dayal
Dec 1, 1991·The Journal of School Health·D C WileyE D Crosman
Jan 1, 1989·Japanese Journal of Medicine·T NakashimaT Takino
Mar 9, 1989·The New England Journal of Medicine·G Salen, G S Tint
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A F Hofmann
Jan 1, 1995·CA: a Cancer Journal for Clinicians·P A WingoS Bolden
May 1, 1994·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·E De KosterM Deltenre
May 12, 1994·The New England Journal of Medicine·R E PouponB Balkau
Jan 1, 1993·Gastroenterology·E BayerdörfferG Paumgartner

❮ Previous
Next ❯

Citations

Nov 20, 2003·Steroids·Tomohiro MatsumotoThies Thiemann
Jun 6, 2000·Mutation Research·T M de Kok, J M van Maanen
Jul 31, 2008·Journal of Separation Science·Yoshio ArakiTakanori Hattori

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.