PMID: 8968389Oct 1, 1996Paper

Studies on new antitumor antibiotics, leptofuranins A, B, C and D.I. Taxonomy, fermentation, isolation and biological activities

The Journal of Antibiotics
Y HayakawaH Seto

Abstract

The retinoblastoma protein (pRB) is inactivated in a wide variety of human cancers. In the course of our screening for antitumor antibiotics by using pRB-inactivated cells, an actinomycete identified as Streptomyces tanashiensis was found to produce four new active substances, leptofuranins A, B, C and D. The leptofuranins arrested the growth of normal cells and induced apoptotic cell death against tumor cells and cells transformed with the adenovirus E1A gene.

Citations

Sep 25, 2015·Cells·Achim DickmannsRalf Ficner
Jan 6, 2006·The Journal of Antibiotics·Zhihao HuHugo Gramajo
Apr 21, 2007·The Journal of Antibiotics·Yoichi HayakawaYoshikazu Shizuri
Jul 19, 2018·The Journal of Antibiotics·Yoichi HayakawaShoko Kimata
Jun 12, 2008·The Journal of Organic Chemistry·Victor P GhiduGary A Sulikowski
Sep 13, 2003·The Journal of Organic Chemistry·James A Marshall, Gregory M Schaaf

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