Studies on peroxidation processes of model membranes and synaptosomes: role of phosphatidic acid

Chemistry and Physics of Lipids
P VianiB Cestaro

Abstract

Dipalmitoylphosphatidic acid (DPPA) was found to exert a strong inhibitory effect on Fe-induced peroxidation of arachidonic acid inserted into liposomal dipalmitoylphosphatidylcholine (DPPC) vesicles. This inhibition was quite effective both below and above the phase transition temperature of the liposomes. Moreover, we demonstrated the antiperoxidative activity of phosphatidic acid (PA) in synaptosomal membranes. PA enriched synaptosomes were prepared by the stimulation of the endogenous phospholipase D activity or by the incubation of the synaptosomes with Streptomyces chromofuscus phospholipase D. The possible contribution of PA to the in vivo defense mechanism against free radical-induced damage is discussed.

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Citations

Mar 24, 2007·European Biophysics Journal : EBJ·Edit SchnitzerDov Lichtenberg
Apr 1, 1994·The International Journal of Biochemistry·P LouP Greenspan
Jan 1, 1992·Free Radical Biology & Medicine·L R McLean, K A Hagaman
Jun 26, 2015·Journal of the Science of Food and Agriculture·Leqi Cui, Eric A Decker
Sep 16, 1991·Biochemical and Biophysical Research Communications·K YoshidaK Takama
Jan 1, 1991·Journal of Neurochemistry·P VianiB Cestaro
Nov 24, 2004·Chemistry and Physics of Lipids·Vânia Rodrigues de LimaTânia Beatriz Creczynski-Pasa
Sep 21, 2005·Organic & Biomolecular Chemistry·Paolo BruniOriano Francescangeli
Oct 1, 2005·The Journal of Biological Chemistry·Robert F Jacob, R Preston Mason
Dec 1, 1990·Chemistry and Physics of Lipids·G CervatoB Cestaro

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