Jun 1, 1975

Studies on peroxisomes. V. Effect of ethyl p-chlorophenoxyisobutyrate on the centrifugal behavior of rat liver peroxisomes

Journal of Biochemistry
H HayashiS Ninobe


After Wistar male rats had been fed on a diet containing 0.25% of ethyl p-chlorophenoxyisobutyrate (CPIB) for 28 days, changes in the enzyme activities and centrifugal behavior of rat liver peroxisomes were investigated. (1) Compared with control rats fed on the basal diet, the catalase [EC] activity of rat livers after the administration of CPIB increased about 2.5-fold, while urate oxidase [EC] activity did not change significantly. Though D-amino acid oxidase [EC] activity markedly decreased to approximately one-sixth of the control, the activity of L-alpha-hydroxy acid oxidase [EC], a flavin enzyme like D-amino acid oxidase, was not affected significnatly after the administration of CPIB. (2) When the hepatic cells of CPIB-treated rats were fractionated by differential centrifugation, most of the increase of catalase activity appeared in the supernatant fraction. A decrease in the hepatic D-amino acid oxidase activity of CPIB-treated rats was observed in all the fractions. As for the subcellular distribution of the particle-bound enzymes, the specific activities of both catalase and urate oxidase of CPIB-treated rat livers were higher in the light mitochondrial fraction than in other fracti...Continue Reading

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Mentioned in this Paper

L-2-hydroxyacid oxidase
Centrifugation, Density Gradient
D-Amino Acid Dehydrogenase
Alcohol Oxidoreductases
Enzymes, antithrombotic
DAO gene
URATE Oxidase

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